PMID- 28966252
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20181202
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 40
IP  - 10
DP  - 2017
TI  - Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin 
      Receptor-Mediated Hair Growth.
PG  - 1784-1788
LID - 10.1248/bpb.b17-00205 [doi]
AB  - Neurotrophins play an important role in the control of the hair growth cycle. 
      Therefore, neurotrophin receptor antagonists have therapeutic potential for the 
      treatment of hair growth disorders. In this study, we investigated the inhibitory 
      effect of Panax ginseng, a medicinal plant commonly used to treat alopecia, on 
      the binding of neurotrophins to their receptors. In addition, we isolated and 
      characterized the bioactive compounds of P. ginseng extracts. P. ginseng hexane 
      extracts strongly inhibited brain-derived neurotrophic factor (BDNF)-TrkB and 
      beta-nerve growth factor (beta-NGF)-p75 neurotrophin receptor (p75NTR) binding. 
      Furthermore, we identified the following 6 polyacetylene compounds as the 
      bioactive components in P. ginseng hexane extract: panaxynol (1), panaxydol (2), 
      panaxydol chlorohydrin (3), 1,8-heptadecadiene-4,6-diyne-3,10-diol (4), 
      panaxytriol (5), and dihydropanaxacol (6). In particular, compounds 4, 5, and 6 
      significantly inhibited BDNF-TrkB binding in a dose-dependent manner. To identify 
      the structural component mediating the inhibitory effect, we investigated the 
      effects of the hydroxyl moiety in these compounds. We found that the inhibitory 
      effect of panaxytriol (5) was strong, whereas the inhibitory effect of 
      Ac-panaxytriol (7) was relatively weak. Our findings suggest that P. 
      ginseng-derived polyacetylenes with a hydroxyl moiety might provide therapeutic 
      benefits to patients with hair growth disorders such as alopecia by inhibiting 
      the binding of neurotrophins to their receptors. Although saponins have been 
      proposed to be the primary mediators of the effects of P. ginseng on hair growth, 
      this study revealed that polyacetylene compounds exert similar effects.
FAU - Suzuki, Aoi
AU  - Suzuki A
AD  - Graduate School of Life and Environmental Sciences, University of Tsukuba.
FAU - Matsuura, Daisuke
AU  - Matsuura D
AD  - Products Development Department, BATHCLIN CORPORATION.
FAU - Kanatani, Hirotoshi
AU  - Kanatani H
AD  - Products Development Department, BATHCLIN CORPORATION.
FAU - Yano, Shingo
AU  - Yano S
AD  - Products Development Department, BATHCLIN CORPORATION.
FAU - Tsunakawa, Mitsuo
AU  - Tsunakawa M
AD  - Products Development Department, BATHCLIN CORPORATION.
FAU - Matsuyama, Shigeru
AU  - Matsuyama S
AD  - Faculty of Life and Environmental Sciences, University of Tsukuba.
FAU - Shigemori, Hideyuki
AU  - Shigemori H
AD  - Faculty of Life and Environmental Sciences, University of Tsukuba.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 25067-58-7 (Polyynes)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Hair/growth & development
MH  - Nerve Growth Factor/*metabolism
MH  - *Panax
MH  - Polyynes/*pharmacology
MH  - Receptor, Nerve Growth Factor/*metabolism
MH  - Receptor, trkB/*metabolism
OTO - NOTNLM
OT  - Panax ginseng
OT  - brain-derived neurotrophic factor
OT  - hair growth
OT  - nerve growth factor
OT  - polyacetylene
EDAT- 2017/10/03 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/10/03 06:00
PHST- 2017/10/03 06:00 [entrez]
PHST- 2017/10/03 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
AID - 10.1248/bpb.b17-00205 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2017;40(10):1784-1788. doi: 10.1248/bpb.b17-00205.