PMID- 28967976
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20231213
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 98
IP  - 1
DP  - 2018 Jan 12
TI  - Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular 
      Psoriasis.
PG  - 5-13
LID - 10.2340/00015555-2808 [doi]
AB  - Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. 
      The therapeutic response to biologics supports the pivotal role of the tumour 
      necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis 
      of these disorders. Recently, functional activation of the IL-36 receptor 
      (IL-36R) was discovered to be another driving force in the pathogenesis of 
      psoriasis. This was first highlighted by the discovery that a loss-of-function 
      mutation of the IL-36R antagonist (IL-36Ra) causes pustular psoriasis. Although 
      the TNF-?/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R are 
      fundamentally involved in plaque psoriasis and pustular psoriasis, respectively, 
      the 2 pathways are closely related and mutually reinforced, resulting in 
      full-blown clinical manifestations. This review summarizes current topics on how 
      IL-36 agonists (IL-36?, IL-36?, IL-36?) signal IL-36R, the pathological 
      expression of IL-36 agonists and IL-36Ra in plaque and pustular psoriatic 
      lesions, and the cross-talk between the TNF-?/IL-23/IL-17/IL-22 axis and the 
      functional activation of IL-36R in the epidermal milieu.
FAU - Furue, Kazuhisa
AU  - Furue K
AD  - Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka, 
      812-8582, Japan.
FAU - Yamamura, Kazuhiko
AU  - Yamamura K
FAU - Tsuji, Gaku
AU  - Tsuji G
FAU - Mitoma, Chikage
AU  - Mitoma C
FAU - Uchi, Hiroshi
AU  - Uchi H
FAU - Nakahara, Takeshi
AU  - Nakahara T
FAU - Kido-Nakahara, Makiko
AU  - Kido-Nakahara M
FAU - Kadono, Takafumi
AU  - Kadono T
FAU - Furue, Masutaka
AU  - Furue M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (IL36A protein, human)
RN  - 0 (IL36B protein, human)
RN  - 0 (IL36G protein, human)
RN  - 0 (IL36RN protein, human)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-23)
RN  - 0 (Interleukins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (interleukin 1F6, mouse)
RN  - 0 (interleukin-36, mouse)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - Humans
MH  - Interleukin-1/genetics/*metabolism
MH  - Interleukin-17/metabolism
MH  - Interleukin-23/metabolism
MH  - Interleukins/genetics/*metabolism
MH  - Keratinocytes
MH  - Loss of Function Mutation
MH  - Psoriasis/*metabolism
MH  - *Signal Transduction
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Interleukin-22
EDAT- 2017/10/03 06:00
MHDA- 2018/02/07 06:00
CRDT- 2017/10/03 06:00
PHST- 2017/10/03 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
PHST- 2017/10/03 06:00 [entrez]
AID - 10.2340/00015555-2808 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2018 Jan 12;98(1):5-13. doi: 10.2340/00015555-2808.