PMID- 28968801
OWN - NLM
STAT- MEDLINE
DCOM- 20171129
LR  - 20171129
IS  - 1464-3553 (Electronic)
IS  - 0379-864X (Linking)
VI  - 42
IP  - 9
DP  - 2017 Oct 31
TI  - The Accessory Olfactory System Facilitates the Recovery of the Attraction to 
      Familiar Volatile Female Odors in Male Mice.
PG  - 737-745
LID - 10.1093/chemse/bjx045 [doi]
AB  - Odors in female mice induce sexual arousal in male mice. Repeated exposure to 
      female odors attenuates male attraction, which recovers when the odors are 
      removed. The neuronal mechanisms for the recovery of male attraction have not 
      been clarified. In this study, we examined how olfactory systems are involved in 
      the recovery of male attraction to female odors following habituation in mice. 
      Presentation with volatile female odors for 5 min induced habituation in males. 
      To evaluate male attraction to familiar volatile female odors, we measured the 
      duration for investigating volatile female odors from the same female mouse, 
      which was presented twice for 5 min with 1-, 3-, or 5-min interval. Intranasal 
      irrigation with ZnSO4 solution almost completely suppressed investigating 
      behavior, indicating that the main olfactory system is indispensable for inducing 
      the attraction to volatile female odors. In contrast, removal of the vomeronasal 
      organ, bilateral lesions of the accessory olfactory bulb (AOB), or 
      pharmacological blockage of neurotransmission in the AOB did not affect the 
      investigation time at the first odor presentation. However, each one of the 
      treatments decreased the investigation time in the second presentation, compared 
      to that in the first presentation, at longer intervals than control treatment, 
      indicating that the disturbance of neurotransmission in the accessory olfactory 
      system delayed the recovery of the attraction attenuated by the first 
      presentation. These results suggest that the accessory olfactory system 
      facilitates the recovery of the attraction to familiar volatile female odors in 
      male mice.
CI  - (c) The Author 2017. Published by Oxford University Press. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Muroi, Yoshikage
AU  - Muroi Y
AD  - Department of Basic Veterinary Medicine, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
FAU - Nishimura, Masakazu
AU  - Nishimura M
AD  - Department of Basic Veterinary Medicine, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
FAU - Ishii, Toshiaki
AU  - Ishii T
AD  - Department of Basic Veterinary Medicine, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - 0 (Sex Attractants)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 7733-02-0 (Zinc Sulfate)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Administration, Intranasal
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Female
MH  - Male
MH  - Mice
MH  - Olfactory Bulb/*drug effects/pathology/physiology
MH  - Olfactory Pathways/drug effects/physiology
MH  - Sex Attractants/analysis/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects/physiology
MH  - Vomeronasal Organ/surgery
MH  - Zinc Sulfate/pharmacology
OTO - NOTNLM
OT  - accessory olfactory system
OT  - habituation
OT  - main olfactory system
OT  - volatile female odors
EDAT- 2017/10/03 06:00
MHDA- 2017/12/01 06:00
CRDT- 2017/10/03 06:00
PHST- 2017/10/03 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
PHST- 2017/10/03 06:00 [entrez]
AID - 4082608 [pii]
AID - 10.1093/chemse/bjx045 [doi]
PST - ppublish
SO  - Chem Senses. 2017 Oct 31;42(9):737-745. doi: 10.1093/chemse/bjx045.