PMID- 28968988
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 38
DP  - 2017 Sep 8
TI  - Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine.
PG  - 63281-63289
LID - 10.18632/oncotarget.18793 [doi]
AB  - Vitamin D deficiency will lead to insulin resistance. In the current study, 
      vitamin D3 1alpha-Hydroxylase ["1alpha(OH)ase"] knockout mice were generated to mimic 
      vitamin D deficiency in vivo. As compared to the wild-type mice, the liver 
      tissues of the knockout mice showed impaired insulin signaling, decreased glucose 
      transporter 4 expression and increased reactive oxygen species production. 
      Meanwhile, p53-p21 activation, apoptosis intensity and pro-inflammatory cytokines 
      (IL-6, IL-1 and MIP-1alpha) level were significantly increased in the knockout mice 
      livers. Significantly, such effects in the knockout mice were largely attenuated 
      by supplement with anti-oxidant n-acetylcysteine (NAC). Remarkably, insulin 
      resistance and metabolic abnormalities in the knockout mice were largely 
      alleviated after treatment of NAC. Therefore, inhibition of oxidative stress by 
      NAC alleviated insulin resistance in vitamin D-deficient mice. Oxidative stress 
      could be the primary cause of insulin resistance by vitamin D deficiency.
FAU - Cui, Zhao-Hui
AU  - Cui ZH
AD  - Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, China.
FAU - Yuan, Qi
AU  - Yuan Q
AD  - Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, China.
FAU - Mao, Li
AU  - Mao L
AD  - Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, China.
FAU - Chen, Feng-Li
AU  - Chen FL
AD  - Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, 
      Huai'an, China.
FAU - Ji, Feng
AU  - Ji F
AD  - Department of Orthopedics, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, China.
FAU - Tao, Sha
AU  - Tao S
AD  - Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical 
      University, Huai'an, China.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5609920
OTO - NOTNLM
OT  - N-acetylcysteine (NAC)
OT  - inflammation
OT  - insulin resistance
OT  - oxidative stress
OT  - vitamin D
COIS- CONFLICTS OF INTEREST The listed authors have no conflicts of interest.
EDAT- 2017/10/04 06:00
MHDA- 2017/10/04 06:01
PMCR- 2017/09/08
CRDT- 2017/10/04 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2017/05/23 00:00 [accepted]
PHST- 2017/10/04 06:00 [entrez]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/10/04 06:01 [medline]
PHST- 2017/09/08 00:00 [pmc-release]
AID - 18793 [pii]
AID - 10.18632/oncotarget.18793 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jun 28;8(38):63281-63289. doi: 10.18632/oncotarget.18793. 
      eCollection 2017 Sep 8.