PMID- 28970694
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0973-6247 (Print)
IS  - 1998-3565 (Electronic)
IS  - 0973-6247 (Linking)
VI  - 11
IP  - 2
DP  - 2017 Jul-Dec
TI  - Daily plasma exchange in severe Guillain-Barre syndrome helps in early weaning 
      from ventilator: A lesson from a case.
PG  - 206-208
LID - 10.4103/0973-6247.214346 [doi]
AB  - Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are 
      well-known therapeutic modalities in Guillain-Barre syndrome (GBS). In developing 
      countries like India, where plasma-derived products (IVIG) are not easily 
      available, and affordable TPE is preferred. Here, we reported a case of severe 
      GBS, who was treated with daily plasma exchange (PLEX) rather than recommended 
      alternate day schedule. A 16-year-old male adolescent of severe GBS, i.e., on 
      mechanical ventilator was treated with the plasmapheresis regimen consisted of 
      removal of 1.3 plasma volumes in each cycle for total of five cycles, on daily 
      basis. The patient's condition started improving after three cycles of TPE with 
      power in the upper limbs 4/5 and lower limbs 3/5 and completely weaned off from 
      ventilator after the 4(th) TPE, i.e. the 4(th) day of admission. This case 
      emphasizes the need of daily PLEX regimen particularly in severe GBS patients 
      because early weaning from ventilator reduces the ventilator-associated 
      complications, hospital stay as wells as less morbidity, and mortality in severe 
      GBS.
FAU - Kaur, Arunpreet
AU  - Kaur A
AD  - Department of Transfusion Medicine and Blood Bank, AIIMS, Jodhpur, Rajasthan, 
      India.
FAU - Bajpayee, Archana
AU  - Bajpayee A
AD  - Department of Transfusion Medicine and Blood Bank, AIIMS, Jodhpur, Rajasthan, 
      India.
FAU - Bajpai, Nitin Kumar
AU  - Bajpai NK
AD  - Department of Transfusion Medicine and Blood Bank, AIIMS, Jodhpur, Rajasthan, 
      India.
FAU - Kothari, Nikhil
AU  - Kothari N
AD  - Department of Transfusion Medicine and Blood Bank, AIIMS, Jodhpur, Rajasthan, 
      India.
LA  - eng
PT  - Case Reports
PL  - India
TA  - Asian J Transfus Sci
JT  - Asian journal of transfusion science
JID - 101306858
PMC - PMC5613433
OTO - NOTNLM
OT  - Mechanical ventilation
OT  - plasma exchange
OT  - severe Guillain-Barre syndrome
OT  - weaning
COIS- There are no conflicts of interest.
EDAT- 2017/10/04 06:00
MHDA- 2017/10/04 06:01
PMCR- 2017/07/01
CRDT- 2017/10/04 06:00
PHST- 2017/10/04 06:00 [entrez]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/10/04 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - AJTS-11-206 [pii]
AID - 10.4103/0973-6247.214346 [doi]
PST - ppublish
SO  - Asian J Transfus Sci. 2017 Jul-Dec;11(2):206-208. doi: 10.4103/0973-6247.214346.