PMID- 28970791
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5188 (Print)
IS  - 1662-5188 (Electronic)
IS  - 1662-5188 (Linking)
VI  - 11
DP  - 2017
TI  - The Slow Dynamics of Intracellular Sodium Concentration Increase the Time Window 
      of Neuronal Integration: A Simulation Study.
PG  - 85
LID - 10.3389/fncom.2017.00085 [doi]
LID - 85
AB  - Changes in intracellular Na(+) concentration ([Na(+)](i)) are rarely taken into 
      account when neuronal activity is examined. As opposed to Ca(2+), [Na(+)](i) 
      dynamics are strongly affected by longitudinal diffusion, and therefore they are 
      governed by the morphological structure of the neurons, in addition to the 
      localization of influx and efflux mechanisms. Here, we examined [Na(+)](i) 
      dynamics and their effects on neuronal computation in three multi-compartmental 
      neuronal models, representing three distinct cell types: accessory olfactory bulb 
      (AOB) mitral cells, cortical layer V pyramidal cells, and cerebellar Purkinje 
      cells. We added [Na(+)](i) as a state variable to these models, and allowed it to 
      modulate the Na(+) Nernst potential, the Na(+)-K(+) pump current, and the 
      Na(+)-Ca(2+) exchanger rate. Our results indicate that in most cases [Na(+)](i) 
      dynamics are significantly slower than [Ca(2+)](i) dynamics, and thus may exert a 
      prolonged influence on neuronal computation in a neuronal type specific manner. 
      We show that [Na(+)](i) dynamics affect neuronal activity via three main 
      processes: reduction of EPSP amplitude in repeatedly active synapses due to 
      reduction of the Na(+) Nernst potential; activity-dependent hyperpolarization due 
      to increased activity of the Na(+)-K(+) pump; specific tagging of active synapses 
      by extended Ca(2+) elevation, intensified by concurrent back-propagating action 
      potentials or complex spikes. Thus, we conclude that [Na(+)](i) dynamics should 
      be considered whenever synaptic plasticity, extensive synaptic input, or bursting 
      activity are examined.
FAU - Zylbertal, Asaph
AU  - Zylbertal A
AD  - Department of Neurobiology, Institute of Life Sciences, The Hebrew University and 
      the Edmond and Lily Safra Center for Brain SciencesJerusalem, Israel.
FAU - Yarom, Yosef
AU  - Yarom Y
AD  - Department of Neurobiology, Institute of Life Sciences, The Hebrew University and 
      the Edmond and Lily Safra Center for Brain SciencesJerusalem, Israel.
FAU - Wagner, Shlomo
AU  - Wagner S
AD  - Sagol Department of Neurobiology, University of HaifaHaifa, Israel.
LA  - eng
PT  - Journal Article
DEP - 20170920
PL  - Switzerland
TA  - Front Comput Neurosci
JT  - Frontiers in computational neuroscience
JID - 101477956
PMC - PMC5609115
OTO - NOTNLM
OT  - mitral cells
OT  - neuronal modeling
OT  - purkinje cells
OT  - pyramidal cells
OT  - sodium dynamics
OT  - sodium-calcium exchanger
OT  - sodium-potassium-exchanging ATPase
EDAT- 2017/10/04 06:00
MHDA- 2017/10/04 06:01
PMCR- 2017/01/01
CRDT- 2017/10/04 06:00
PHST- 2017/03/27 00:00 [received]
PHST- 2017/09/04 00:00 [accepted]
PHST- 2017/10/04 06:00 [entrez]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/10/04 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fncom.2017.00085 [doi]
PST - epublish
SO  - Front Comput Neurosci. 2017 Sep 20;11:85. doi: 10.3389/fncom.2017.00085. 
      eCollection 2017.