PMID- 28971155
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2452-2473 (Print)
IS  - 2452-2473 (Electronic)
IS  - 2452-2473 (Linking)
VI  - 17
IP  - 3
DP  - 2017 Sep
TI  - Comparison of ketamine/propofol (ketofol) and etomidate/fentanyl (etofen) 
      combinations for procedural sedation and analgesia in the emergency department: 
      An observational study.
PG  - 89-94
LID - 10.1016/j.tjem.2017.01.003 [doi]
AB  - OBJECTIVES: The primary aim of this study was to report the vital signs, 
      hemodynamic parameters and pain scores of the patients who have received 
      procedural sedation and analgesia (PSA) with either ketofol (combination of 
      ketamine and propofol) or etofen (combination of etomidate and fentanyl) and 
      compare the proportion of patients with airway or respiratory adverse events 
      (AEs) requiring an intervention and calculate the relative risk of AEs with each 
      combination. METHODS: This study is a prospective observational study with survey 
      analysis. All patients received procedural sedation and analgesia (PSA) with 
      either ketofol (combination of ketamine and propofol) or etofen (combination of 
      etomidate and fentanyl) were prospectively observed. Vital and hemodynamic 
      parameters and pain scores of the patients were recorded by automated equipment 
      and visual analog scale (VAS) charts. RESULTS: 112 patients were enrolled, 55 
      received ketofol and 57 received etofen. All patients with a respiratory AE 
      (n = 27) observed to receive a respiratory intervention. Respiratory AE rate and 
      proportion of patient who required a respiratory intervention were significantly 
      higher with ketofol (p = 0.0029). Overall AE rate, and rates of desaturation, 
      emergence reaction were also significantly higher in ketofol group. CONCLUSION: 
      Etofen is a promising combination for the PSA of adult patients with lower 
      respiratory AE and intervention rates and with better hemodynamic profile.
FAU - Sanri, Erkman
AU  - Sanri E
AD  - Marmara University Pendik Education and Research Hospital, Department of 
      Emergency Medicine, Istanbul, Turkey.
FAU - Karacabey, Sinan
AU  - Karacabey S
AD  - Bozok University, Faculty of Medicine, Department of Emergency Medicine, Yozgat, 
      Turkey.
FAU - Akoglu, Haldun
AU  - Akoglu H
AD  - Marmara University, Faculty of Medicine, Department of Emergency Medicine, 
      Istanbul, Turkey.
FAU - Kaya, Bora
AU  - Kaya B
AD  - Kocaeli Derince Education and Research Hospital, Department of Emergency 
      Medicine, Kocaeli, Turkey.
FAU - Guneysel, Ozlem
AU  - Guneysel O
AD  - Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Emergency 
      Medicine, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170319
PL  - India
TA  - Turk J Emerg Med
JT  - Turkish journal of emergency medicine
JID - 101681782
PMC - PMC5608606
OTO - NOTNLM
OT  - Emergency department
OT  - Etomidate
OT  - Fentanyl
OT  - Ketamine
OT  - Procedural sedation
OT  - Propofol
EDAT- 2017/10/04 06:00
MHDA- 2017/10/04 06:01
PMCR- 2017/03/19
CRDT- 2017/10/04 06:00
PHST- 2016/10/17 00:00 [received]
PHST- 2017/01/05 00:00 [revised]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/10/04 06:00 [entrez]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/10/04 06:01 [medline]
PHST- 2017/03/19 00:00 [pmc-release]
AID - S2452-2473(16)30233-3 [pii]
AID - 10.1016/j.tjem.2017.01.003 [doi]
PST - epublish
SO  - Turk J Emerg Med. 2017 Mar 19;17(3):89-94. doi: 10.1016/j.tjem.2017.01.003. 
      eCollection 2017 Sep.