PMID- 28971480
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20180408
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 142
IP  - 3
DP  - 2018 Feb 1
TI  - Cancer survival in people with AIDS: A population-based study from Sao Paulo, 
      Brazil.
PG  - 524-533
LID - 10.1002/ijc.31081 [doi]
AB  - Cancer survival among people with AIDS (PWA) has been described in developed 
      countries, but there is lack of data from developing countries. The aim of this 
      study was to evaluate survival after cancer diagnosis in PWA and compare it with 
      people without AIDS (non-PWA) in Sao Paulo, Brazil. A probabilistic record 
      linkage was carried out between the databases of the Population-based Cancer 
      Registry of Sao Paulo (PBCR-SP) and the AIDS registry of SP (SINAN) to identify 
      PWA who developed cancer. For comparison, non-PWA were frequency matched from the 
      PBCR-SP by cancer site/type, sex, age, and period. Hazard ratio (HR) stratified 
      by matching variables was estimated using a Cox proportional hazards model. A 
      total of 1,294 PWA (20 patients with two primary site tumors) were included in 
      the site/type-specific analyses. AIDS-defining cancers (ADC) comprised 51.9% of 
      cases assessed. The all-cancer 5-year overall survival in PWA was 49.4% versus 
      72.7% in non-PWA (HR = 2.64; 95%CI = 2.39-2.91). Survival was impaired in PWA for 
      both ADC (HR = 2.93; 95%CI = 2.49-3.45) and non-ADC (HR = 2.51; 
      95%CI = 2.21-2.84), including bladder (HR = 8.11; 95% CI = 2.09-31.52), lung 
      (HR = 2.93; 95%CI = 1.97-4.36) and anal cancer (HR = 2.53; 95%CI = 1.63-3.94). 
      These disparities were seen mainly in the first year after cancer diagnosis. The 
      overall survival was significantly lower in PWA in comparison with non-PWA in Sao 
      Paulo, as seen in high-income countries. Efforts to enhance early diagnosis and 
      ensure proper cancer treatment in PWA should be emphasized.
CI  - (c) 2017 UICC.
FAU - Tanaka, Luana F
AU  - Tanaka LF
AUID- ORCID: 0000-0002-2086-7491
AD  - Center for International Health, Medical Center of the University of Munich 
      (LMU), Munich, Germany.
AD  - Department of Epidemiology, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
AD  - Population-Based Cancer Registry of Sao Paulo, Department of Epidemiology, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Latorre, Maria do Rosario D O
AU  - Latorre MDRDO
AD  - Department of Epidemiology, School of Public Health, University of Sao Paulo, Sao 
      Paulo, Brazil.
AD  - Population-Based Cancer Registry of Sao Paulo, Department of Epidemiology, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Gutierrez, Eliana B
AU  - Gutierrez EB
AD  - Municipal STD-AIDS Program, Secretaria Municipal de Saude, Sao Paulo, Brazil.
FAU - Curado, Maria P
AU  - Curado MP
AD  - A. C. Camargo Cancer Center, Sao Paulo, Brazil.
AD  - International Prevention Research Institute, Lyon, France.
FAU - Dal Maso, Luigino
AU  - Dal Maso L
AUID- ORCID: 0000-0001-6163-200X
AD  - Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, 
      Italy.
FAU - Herbinger, Karl-Heinz
AU  - Herbinger KH
AD  - Division of Infectious Diseases and Tropical Medicine, Medical Center of the 
      University of Munich (LMU), Munich, Germany.
FAU - Froeschl, Guenter
AU  - Froeschl G
AD  - Center for International Health, Medical Center of the University of Munich 
      (LMU), Munich, Germany.
AD  - Division of Infectious Diseases and Tropical Medicine, Medical Center of the 
      University of Munich (LMU), Munich, Germany.
FAU - Heumann, Christian
AU  - Heumann C
AD  - Department of Statistics, University of Munich (LMU), Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171016
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*mortality/*pathology
MH  - Adult
MH  - Brazil/epidemiology
MH  - Developing Countries
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*mortality/*virology
MH  - Proportional Hazards Models
MH  - Registries
OTO - NOTNLM
OT  - HIV/AIDS
OT  - cancer
OT  - epidemiology
OT  - medical record linkage
OT  - survival
EDAT- 2017/10/04 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/10/04 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/08/11 00:00 [revised]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2017/10/04 06:00 [entrez]
AID - 10.1002/ijc.31081 [doi]
PST - ppublish
SO  - Int J Cancer. 2018 Feb 1;142(3):524-533. doi: 10.1002/ijc.31081. Epub 2017 Oct 
      16.