PMID- 2897228
OWN - NLM
STAT- MEDLINE
DCOM- 19880630
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 446
IP  - 1
DP  - 1988 Apr 12
TI  - Toxic effects of MDMA on central serotonergic neurons in the primate: importance 
      of route and frequency of drug administration.
PG  - 165-8
AB  - This study compared the toxic effects of oral versus subcutaneous and single 
      versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central 
      serotonergic neurons in non-human primates. Orally administered MDMA was 
      approximately one-half as effective as subcutaneously administered drug. Multiple 
      doses were more effective than single doses, but a single 5 mg/kg dose of MDMA 
      given orally still produced a long-lasting depletion of serotonin in the monkey 
      brain. These results indicate that when MDMA is given to monkeys in a manner 
      similar to that employed by humans, it exerts toxic effects on central 
      serotonergic neurons. This suggests that humans using MDMA may be at risk for 
      incurring central serotonergic neuronal damage.
FAU - Ricaurte, G A
AU  - Ricaurte GA
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, 
      MD 21205.
FAU - DeLanney, L E
AU  - DeLanney LE
FAU - Irwin, I
AU  - Irwin I
FAU - Langston, J W
AU  - Langston JW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amphetamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/analogs & 
      derivatives/*toxicity
MH  - Administration, Oral
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Brain/drug effects/*metabolism/pathology
MH  - Drug Administration Schedule
MH  - Injections, Subcutaneous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Neurons/drug effects/*metabolism
MH  - Organ Specificity
MH  - Saimiri
MH  - Serotonin/*metabolism
EDAT- 1988/04/12 00:00
MHDA- 1988/04/12 00:01
CRDT- 1988/04/12 00:00
PHST- 1988/04/12 00:00 [pubmed]
PHST- 1988/04/12 00:01 [medline]
PHST- 1988/04/12 00:00 [entrez]
AID - 0006-8993(88)91309-1 [pii]
AID - 10.1016/0006-8993(88)91309-1 [doi]
PST - ppublish
SO  - Brain Res. 1988 Apr 12;446(1):165-8. doi: 10.1016/0006-8993(88)91309-1.