PMID- 28972396
OWN - NLM
STAT- MEDLINE
DCOM- 20180615
LR  - 20220330
IS  - 1362-301X (Electronic)
IS  - 0269-9052 (Linking)
VI  - 31
IP  - 11
DP  - 2017
TI  - Intranasal Nerve Growth Factor administration improves cerebral functions in a 
      child with severe traumatic brain injury: A case report.
PG  - 1538-1547
LID - 10.1080/02699052.2017.1376760 [doi]
AB  - BACKGROUND: Nerve growth factor (NGF) promotes neural recovery after experimental 
      traumatic brain injury (TBI) supporting neuronal growth, differentiation and 
      survival of brain cells and up-regulating the neurogenesis-associated protein 
      Doublecortin (DCX). Only a few studies reported NGF administration in paediatric 
      patients with severe TBI. METHODS: A four-year-old boy in a persistent 
      unresponsive wakefulness syndrome (UWS) was treated with intranasal murine NGF 
      administration 6 months after severe TBI. The patient received four cycles of 
      intranasal NGF (0.1 mg/kg, twice a day for 10 consecutive days). RESULTS: NGF 
      administration improved functional [Positron Emission Tomography/Computed 
      Tomography (PET/CT); Single photon emission/Computed Tomography (SPECT/CT) and 
      Magnetic Resonance Imaging (MRI)] assessment, electrophysiological 
      [Electroencephalogram (EEG) and Visual Evoked Potential (VEP)] studies and 
      clinical conditions. He showed improvements in voluntary movements, facial 
      mimicry, phonation, attention and verbal comprehension, ability to cry, cough 
      reflex, oral motility, feeding capacity, and bowel and urinary functions. After 
      NGF administration, raised levels of both NGF and DCX were found in the 
      cerebrospinal fluid of the patient. No side effects were reported. CONCLUSIONS: 
      Although further studies are needed for better understanding the neuroprotective 
      role of this neurotrophin, intranasal NGF administration appears to be a 
      promising and safe rescuing strategy treatment in children with neurological 
      impairment after TBI.
FAU - Chiaretti, Antonio
AU  - Chiaretti A
AD  - a Institute of Pediatrics , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Conti, Giorgio
AU  - Conti G
AD  - b Pediatric Intensive Care Unit , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Falsini, Benedetto
AU  - Falsini B
AD  - c Institute of Ophthalmology , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Buonsenso, Danilo
AU  - Buonsenso D
AD  - a Institute of Pediatrics , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Crasti, Matteo
AU  - Crasti M
AD  - a Institute of Pediatrics , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Manni, Luigi
AU  - Manni L
AD  - d Institute of Translational Pharmacology , CNR , Rome , Italy.
FAU - Soligo, Marzia
AU  - Soligo M
AD  - d Institute of Translational Pharmacology , CNR , Rome , Italy.
FAU - Fantacci, Claudia
AU  - Fantacci C
AD  - a Institute of Pediatrics , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Genovese, Orazio
AU  - Genovese O
AD  - b Pediatric Intensive Care Unit , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Calcagni, Maria Lucia
AU  - Calcagni ML
AD  - e Institute of Nuclear Medicine , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Di Giuda, Daniela
AU  - Di Giuda D
AD  - e Institute of Nuclear Medicine , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Mattoli, Maria Vittoria
AU  - Mattoli MV
AD  - e Institute of Nuclear Medicine , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Cocciolillo, Fabrizio
AU  - Cocciolillo F
AD  - e Institute of Nuclear Medicine , Universita Cattolica del Sacro Cuore , Rome , 
      Italy.
FAU - Ferrara, Pietro
AU  - Ferrara P
AD  - a Institute of Pediatrics , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Ruggiero, Antonio
AU  - Ruggiero A
AD  - f Pediatric Oncology , Universita Cattolica del Sacro Cuore , Rome , Italy.
FAU - Staccioli, Susanna
AU  - Staccioli S
AD  - g Department of Neuroscience and Neurorehabilitation , Bambino Gesu Children's 
      Hospital , Rome , Italy.
FAU - Colafati, Giovanna Stefania
AU  - Colafati GS
AD  - h Department of Imaging, Neuroradiology Unit , Bambino Gesu Children's Hospital , 
      Rome , Italy.
FAU - Riccardi, Riccardo
AU  - Riccardi R
AD  - f Pediatric Oncology , Universita Cattolica del Sacro Cuore , Rome , Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171003
PL  - England
TA  - Brain Inj
JT  - Brain injury
JID - 8710358
RN  - 0 (DCX protein, human)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Administration, Intranasal
MH  - Brain Injuries, Traumatic/diagnostic imaging/*drug therapy
MH  - Cerebral Cortex/diagnostic imaging/*drug effects/physiology
MH  - Child, Preschool
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Electroencephalography
MH  - Evoked Potentials, Visual/drug effects
MH  - Fluorodeoxyglucose F18/pharmacokinetics
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Male
MH  - Microtubule-Associated Proteins/metabolism
MH  - Nerve Growth Factor/*administration & dosage
MH  - Neuroimaging
MH  - Neurologic Examination
MH  - Neuropeptides/metabolism
OTO - NOTNLM
OT  - Doublecortin
OT  - Nerve Growth Factor
OT  - intranasal administration
OT  - traumatic brain injury
EDAT- 2017/10/04 06:00
MHDA- 2018/06/16 06:00
CRDT- 2017/10/04 06:00
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2018/06/16 06:00 [medline]
PHST- 2017/10/04 06:00 [entrez]
AID - 10.1080/02699052.2017.1376760 [doi]
PST - ppublish
SO  - Brain Inj. 2017;31(11):1538-1547. doi: 10.1080/02699052.2017.1376760. Epub 2017 
      Oct 3.