PMID- 28973554
OWN - NLM
STAT- MEDLINE
DCOM- 20190911
LR  - 20191008
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Print)
IS  - 0148-396X (Linking)
VI  - 82
IP  - 6
DP  - 2018 Jun 1
TI  - Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of 
      Ferumoxytol.
PG  - 770-780
LID - 10.1093/neuros/nyx357 [doi]
AB  - Physiological and pathological processes that increase or decrease the central 
      nervous system's need for nutrients and oxygen via changes in local blood supply 
      act primarily at the level of the neurovascular unit (NVU). The NVU consists of 
      endothelial cells, associated blood-brain barrier tight junctions, basal lamina, 
      pericytes, and parenchymal cells, including astrocytes, neurons, and 
      interneurons. Knowledge of the NVU is essential for interpretation of central 
      nervous system physiology and pathology as revealed by conventional and advanced 
      imaging techniques. This article reviews current strategies for interrogating the 
      NVU, focusing on vascular permeability, blood volume, and functional imaging, as 
      assessed by ferumoxytol an iron oxide nanoparticle.
FAU - Netto, Joao Prola
AU  - Netto JP
AD  - Department of Neurology, Oregon Health & Science University, Portland, Oregon.
AD  - Department of Neuroradiology, Oregon Health & Science University, Portland, 
      Oregon.
FAU - Iliff, Jeffrey
AU  - Iliff J
AD  - Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science 
      University, Portland, Oregon.
FAU - Stanimirovic, Danica
AU  - Stanimirovic D
AD  - Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, 
      Ontario, Canada.
FAU - Krohn, Kenneth A
AU  - Krohn KA
AD  - Department of Radiology, University of Washington, Seattle, Washington.
AD  - Department of Radiology, Oregon Health & Science University, Portland, Oregon.
FAU - Hamilton, Bronwyn
AU  - Hamilton B
AD  - Department of Neuroradiology, Oregon Health & Science University, Portland, 
      Oregon.
FAU - Varallyay, Csanad
AU  - Varallyay C
AD  - Department of Neurology, Oregon Health & Science University, Portland, Oregon.
AD  - Department of Radiology, Oregon Health & Science University, Portland, Oregon.
FAU - Gahramanov, Seymur
AU  - Gahramanov S
AD  - Department of Neurosurgery, University of New Mexico, Albuquerque, New Mexico.
FAU - Daldrup-Link, Heike
AU  - Daldrup-Link H
AD  - Department of Radiology, Stanford University, Stanford, California.
FAU - d'Esterre, Christopher
AU  - d'Esterre C
AD  - Department of Radiology, University of Calgary, Foothills Medical Center, 
      Calgary, Alberta, Canada.
FAU - Zlokovic, Berislav
AU  - Zlokovic B
AD  - Zikha Neurogenetic Institute, University of Southern California, Los Angeles, 
      California.
FAU - Sair, Haris
AU  - Sair H
AD  - Department of Radiology and Radiological Science, Johns Hopkins University, 
      Baltimore, Maryland.
FAU - Lee, Yueh
AU  - Lee Y
AD  - Department of Radiology, The University of North Carolina at Chapel Hill, Chapel 
      Hill, North Carolina.
FAU - Taheri, Saeid
AU  - Taheri S
AD  - Department of Radiology and Radiological Sciences, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Jain, Rajan
AU  - Jain R
AD  - Department of Radiology and Neurosurgery, New York University School of Medicine, 
      New York, New York.
FAU - Panigrahy, Ashok
AU  - Panigrahy A
AD  - Department of Radiology, Children's Hospital of Pittsburgh, Pittsburgh, 
      Pennsylvania.
FAU - Reich, Daniel S
AU  - Reich DS
AD  - Translational Neuroradiology Unit, National Institute of Neurological Disorders 
      and Stroke, National Institutes of Health, Bethesda, Maryland.
FAU - Drewes, Lester R
AU  - Drewes LR
AD  - Department of Biomedical Sciences, University of Minnesota, Duluth, Minnesota.
FAU - Castillo, Mauricio
AU  - Castillo M
AD  - Department of Radiology, The University of North Carolina at Chapel Hill, Chapel 
      Hill, North Carolina.
FAU - Neuwelt, Edward A
AU  - Neuwelt EA
AD  - Department of Neurology, Oregon Health & Science University, Portland, Oregon.
AD  - Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon.
AD  - Portland Veterans Affairs Medical Center, Portland, Oregon.
LA  - eng
GR  - P01 AG052350/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
RN  - 0 (Contrast Media)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*diagnostic imaging/physiology
MH  - *Contrast Media
MH  - *Ferrosoferric Oxide
MH  - Humans
MH  - *Metal Nanoparticles
MH  - Neuroimaging/*methods
PMC - PMC6256943
EDAT- 2017/10/04 06:00
MHDA- 2019/09/12 06:00
PMCR- 2019/06/01
CRDT- 2017/10/04 06:00
PHST- 2016/06/10 00:00 [received]
PHST- 2017/06/27 00:00 [accepted]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2019/09/12 06:00 [medline]
PHST- 2017/10/04 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 3988111 [pii]
AID - nyx357 [pii]
AID - 10.1093/neuros/nyx357 [doi]
PST - ppublish
SO  - Neurosurgery. 2018 Jun 1;82(6):770-780. doi: 10.1093/neuros/nyx357.