PMID- 28973679
OWN - NLM
STAT- MEDLINE
DCOM- 20190916
LR  - 20190916
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 83
IP  - 2
DP  - 2018 Aug 1
TI  - The Minimal Clinically Important Difference of the Anterior Skull Base Nasal 
      Inventory-12.
PG  - 277-280
LID - 10.1093/neuros/nyx401 [doi]
AB  - BACKGROUND: The minimal clinically important difference (MCID) is defined as the 
      smallest change in health-related quality of life (QOL) that patients consider 
      meaningful. The MCID is essential for determining clinically significant changes, 
      rather than simply statistically significant changes, in QOL scores. The Anterior 
      Skull Base Nasal Inventory-12 (ASK Nasal-12), a site-specific sinonasal QOL 
      instrument, has emerged as a standard instrument for assessing QOL in patients 
      who have undergone endonasal transsphenoidal surgery. OBJECTIVE: To determine the 
      MCID for the ASK Nasal-12. METHODS: Distribution- and anchor-based methods were 
      used to determine the MCID for the ASK Nasal-12 based on raw data from a 
      multicenter prospective QOL study of 218 patients. RESULTS: Two 
      distribution-based statistical methods, the one-half standard deviation method 
      and the effect-size method, both yielded MCIDs of 0.37 (medium effect). The first 
      anchor-based method, using the 2-wk postoperative overall nasal functioning item 
      as the anchor, yielded an MCID of 0.31. The second anchor-based method, using the 
      2-wk postoperative Short Form Health Survey 8 bodily pain item as the anchor, 
      yielded an MCID of 0.29. CONCLUSION: The largest MCID obtained for the ASK 
      Nasal-12 using 4 statistical methods 2 wk postoperatively was 0.37. This 
      information provides clinicians with an essential context for determining the 
      clinical significance of changes in QOL scores after interventions. Our results 
      will help clinicians better interpret QOL scores and design future studies that 
      are powered to detect meaningful QOL changes.
FAU - Gravbrot, Nicholas
AU  - Gravbrot N
AD  - Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hos-pital 
      and Medical Center, Phoenix, Ari-zona.
FAU - Kelly, Daniel F
AU  - Kelly DF
AD  - Pacific Pituitary Disorders Center, John Wayne Cancer Institute, Saint John's 
      Health Center, Santa Monica, California.
FAU - Milligan, John
AU  - Milligan J
AD  - Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hos-pital 
      and Medical Center, Phoenix, Ari-zona.
FAU - Griffiths, Chester F
AU  - Griffiths CF
AD  - Pacific Pituitary Disorders Center, John Wayne Cancer Institute, Saint John's 
      Health Center, Santa Monica, California.
FAU - Barkhoudarian, Garni
AU  - Barkhoudarian G
AD  - Pacific Pituitary Disorders Center, John Wayne Cancer Institute, Saint John's 
      Health Center, Santa Monica, California.
FAU - Jahnke, Heidi
AU  - Jahnke H
AD  - Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hos-pital 
      and Medical Center, Phoenix, Ari-zona.
FAU - White, William L
AU  - White WL
AD  - Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hos-pital 
      and Medical Center, Phoenix, Ari-zona.
FAU - Little, Andrew S
AU  - Little AS
AD  - Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hos-pital 
      and Medical Center, Phoenix, Ari-zona.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Neurosurgical Procedures/adverse effects/*methods
MH  - Nose
MH  - Pituitary Neoplasms/*surgery
MH  - Postoperative Complications/epidemiology/etiology
MH  - Prospective Studies
MH  - Quality of Life
MH  - Sella Turcica/*surgery
MH  - Skull Base/surgery
MH  - Young Adult
EDAT- 2017/10/04 06:00
MHDA- 2019/09/17 06:00
CRDT- 2017/10/04 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/10/04 06:00 [pubmed]
PHST- 2019/09/17 06:00 [medline]
PHST- 2017/10/04 06:00 [entrez]
AID - 4064761 [pii]
AID - 10.1093/neuros/nyx401 [doi]
PST - ppublish
SO  - Neurosurgery. 2018 Aug 1;83(2):277-280. doi: 10.1093/neuros/nyx401.