PMID- 28977115
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20171226
IS  - 1678-4219 (Electronic)
IS  - 0004-2803 (Linking)
VI  - 54
IP  - 4
DP  - 2017 Dec
TI  - EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER 
      PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER.
PG  - 297-299
LID - S0004-28032017005011103 [pii]
AB  - BACKGROUND: As being the first bacteria determined to be carcinogenic, 
      Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more 
      than half of the world population. Some earlier studies have found a relation 
      between tissue histocompatibility antigens and gastric cancers depending on the 
      regions. OBJECTIVE: The present study aimed to determine the distribution of 
      human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive 
      pediatric patients with active gastritis and duodenal ulcer, excluding cancer 
      cases, in our center. METHODS: The study included 40 patients diagnosed with H. 
      pylori-positive active gastritis and duodenal ulcer and 100 controls consisting 
      of healthy donor candidates. The HLA class I and class II antigens were studied 
      in the isolated DNA samples using the polymerase chain reaction sequence-specific 
      oligonucleotide probes. RESULTS: The frequency of HLA-B*51 antigen was 
      significantly higher in the patient group than in the control group (40% vs 17%; 
      P=0.003). There was no difference between the two groups in terms of the 
      frequencies of HLA-A, HLA-C, HLA-DR, and HLA-DQ antigens. CONCLUSION: It was 
      determined that HLA-B*51 plays a critical role in H. pylori infection.
FAU - Gonen, Sevim
AU  - Gonen S
AD  - Laboratory of Tissue Typing and Pediatric Nephrology, Faculty of Medicine, Gazi 
      University, Ankara, Turkey.
FAU - Sari, Sinan
AU  - Sari S
AD  - Department of Pediatric Gastroenterology, Faculty of Medicine, Gazi University, 
      Ankara, Turkey.
FAU - Kandur, Yasar
AU  - Kandur Y
AD  - Department of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, 
      Turkey.
FAU - Dalgic, Buket
AU  - Dalgic B
AD  - Department of Pediatric Gastroenterology, Faculty of Medicine, Gazi University, 
      Ankara, Turkey.
FAU - Soylemezoglu, Oguz
AU  - Soylemezoglu O
AD  - Department of Pediatric Nephrology, Faculty of Medicine, Gazi University, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171002
PL  - Brazil
TA  - Arq Gastroenterol
JT  - Arquivos de gastroenterologia
JID - 15310600R
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Duodenal Ulcer/*immunology
MH  - Female
MH  - Gastritis/*immunology/microbiology
MH  - Helicobacter Infections/complications/*immunology
MH  - *Helicobacter pylori
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Male
EDAT- 2017/10/05 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/10/05 06:00
PHST- 2017/07/12 00:00 [received]
PHST- 2017/08/30 00:00 [accepted]
PHST- 2017/10/05 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/10/05 06:00 [entrez]
AID - S0004-28032017005011103 [pii]
AID - 10.1590/S0004-2803.201700000-62 [doi]
PST - ppublish
SO  - Arq Gastroenterol. 2017 Dec;54(4):297-299. doi: 10.1590/S0004-2803.201700000-62. 
      Epub 2017 Oct 2.