PMID- 28977395
OWN - NLM
STAT- MEDLINE
DCOM- 20190218
LR  - 20190219
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Jun 1
TI  - Mechanics and prognostic value of left and right ventricular dysfunction in 
      patients with systemic sclerosis.
PG  - 660-667
LID - 10.1093/ehjci/jex147 [doi]
AB  - AIMS: Impairment of myocardial function is an important potential complication of 
      systemic sclerosis (SSc) and associated with poor prognosis. The detection of 
      left (LV) and right ventricular (RV) dysfunction may prompt specific therapeutic 
      interventions. We sought to investigate the prognostic value of both LV and RV 
      deformation in patients with SSc. METHODS AND RESULTS: Speckle tracking LV strain 
      parameters [global longitudinal strain (GLS) and global circumferential strain 
      (GCS)] and tricuspid annular peak systolic velocity (Ts') were measured in 103 
      patients with SSc and 103 age- and gender-matched controls. Subjects were 
      followed for a median of 3.4 years for heart failure-specific admission or death, 
      and the association of the study parameters with outcome was assessed using Cox 
      proportional hazards models. GLS, GCS, and Ts' were significantly impaired in 
      patients with SSc, even without pulmonary hypertension, compared with controls. 
      GCS (r2 = 0.07, P = 0.03) but not GLS (r2 = 0.04, P = 0.11) was associated with 
      systolic pulmonary artery pressure. During follow-up, SSc patients (n = 17, 17%) 
      had more events than controls (n = 7, 7%, P = 0.04). In SSc patients, GCS (but 
      not GLS), Ts', and 6-minute walk distance (6MWD) were significantly associated 
      with outcome. 6MWD and Ts' (but not GCS) were independently associated with 
      outcome. A model based on age, gender, 6MWD, and GCS was significantly improved 
      by adding by adding Ts' (P = 0.02). CONCLUSION: RV dysfunction was associated 
      with adverse outcome, independent of and incremental to clinical and LV 
      deformation parameters in SSc. LV dysfunction appears to have less prognostic 
      relevance than RV dysfunction.
FAU - Saito, Makoto
AU  - Saito M
AD  - Menzies Institute for Medical Research, 17 Liverpool St, University of Tasmania, 
      Hobart TAS 7000, Australia.
FAU - Wright, Leah
AU  - Wright L
AD  - Menzies Institute for Medical Research, 17 Liverpool St, University of Tasmania, 
      Hobart TAS 7000, Australia.
AD  - Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, 
      Australia.
FAU - Negishi, Kazuaki
AU  - Negishi K
AD  - Menzies Institute for Medical Research, 17 Liverpool St, University of Tasmania, 
      Hobart TAS 7000, Australia.
FAU - Dwyer, Nathan
AU  - Dwyer N
AD  - Royal Hobart Hospital, 48 Liverpool St Hobart TAS 7000, Australia.
FAU - Marwick, Thomas H
AU  - Marwick TH
AD  - Menzies Institute for Medical Research, 17 Liverpool St, University of Tasmania, 
      Hobart TAS 7000, Australia.
AD  - Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, 
      Australia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Area Under Curve
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Echocardiography, Doppler/*methods
MH  - Female
MH  - Heart Function Tests
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Scleroderma, Systemic/*complications/diagnosis
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Survival Rate
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*etiology/*physiopathology
MH  - Ventricular Dysfunction, Right/diagnostic imaging/*etiology/*physiopathology
EDAT- 2017/10/05 06:00
MHDA- 2019/02/20 06:00
CRDT- 2017/10/05 06:00
PHST- 2016/12/14 00:00 [received]
PHST- 2017/06/04 00:00 [accepted]
PHST- 2017/10/05 06:00 [pubmed]
PHST- 2019/02/20 06:00 [medline]
PHST- 2017/10/05 06:00 [entrez]
AID - 4057504 [pii]
AID - 10.1093/ehjci/jex147 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):660-667. doi: 
      10.1093/ehjci/jex147.