PMID- 28977521
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20221207
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 20
IP  - 10
DP  - 2017 Oct 1
TI  - The Impact of BDNF Polymorphisms on Suicidality in Treatment-Resistant Major 
      Depressive Disorder: A European Multicenter Study.
PG  - 782-787
LID - 10.1093/ijnp/pyx028 [doi]
AB  - BACKGROUND: Numerous studies have reported associations between the brain-derived 
      neurotrophic factor (BDNF) gene and psychiatric disorders, including suicidal 
      behavior, although with conflicting results. METHODS: A total of 250 major 
      depressive disorder patients were collected in the context of a European 
      multicenter resistant depression study and treated with antidepressants at 
      adequate doses for at least 4 weeks. Suicidality was assessed using the Mini 
      International Neuropsychiatric Interview and Hamilton Rating Scale for 
      Depression, and treatment response using the HAM-D. Genotyping was performed for 
      the functional Val66Met polymorphism (rs6265) and 7 additional tagging single 
      nucleotide polymorphisms within the BDNF gene. RESULTS: Neither BDNF single 
      markers nor haplotypes were found to be associated with suicide risk and lifetime 
      history of suicide attempts. Gender-specific analyses revealed nonsignificant 
      single marker (rs908867) and haplotypic association with suicide risk in males 
      after multiple testing correction. Analyzing treatment response phenotypes, the 
      functional Val66Met polymorphism as well as rs10501087 showed significant 
      genotypic and haplotypic association with suicide risk in remitters (n=34, 
      13.6%). CONCLUSIONS: Considering the sample size, the present findings need to be 
      replicated in larger samples to confirm or refute a role of BDNF in the 
      investigated suicidal behavior phenotypes.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of CINP.
FAU - Schosser, Alexandra
AU  - Schosser A
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Carlberg, Laura
AU  - Carlberg L
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Calati, Raffaella
AU  - Calati R
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Serretti, Alessandro
AU  - Serretti A
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Massat, Isabel
AU  - Massat I
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Spindelegger, Christoph
AU  - Spindelegger C
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Linotte, Sylvie
AU  - Linotte S
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Mendlewicz, Julien
AU  - Mendlewicz J
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Souery, Daniel
AU  - Souery D
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Zohar, Joseph
AU  - Zohar J
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Montgomery, Stuart
AU  - Montgomery S
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
FAU - Kasper, Siegfried
AU  - Kasper S
AD  - Department of Psychiatry and Psychotherapy, Medical University, Vienna, Austria; 
      Zentrum fur Seelische Gesundheit, Leopoldau, Austria; INSERM U1061, University of 
      Montpellier, FondaMental Foundation, Montpellier, France; Department of 
      Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 
      Laboratory of Experimental Neurology, National Fund of Scientific Research, 
      Brussels, Belgium; Universite Libre de Bruxelles, Brussels, Belgium; Laboratoire 
      de Psychologie Medicale, Universite Libre de Bruxelles and Psy Pluriel, Centre 
      Europe en de Psychologie Medicale, Brussels, Belgium; Chaim Sheba Medical Center, 
      Tel-Hashomer, Israel; Imperial College, School of Medicine, University of London, 
      United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/drug therapy/*genetics
MH  - Depressive Disorder, Treatment-Resistant/drug therapy/*genetics
MH  - Europe
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Psychiatric Status Rating Scales
MH  - Sex Factors
MH  - *Suicide
MH  - White People
PMC - PMC5632306
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - pharmacogenetic
OT  - suicidality
EDAT- 2017/10/05 06:00
MHDA- 2018/06/06 06:00
PMCR- 2017/06/27
CRDT- 2017/10/05 06:00
PHST- 2016/12/20 00:00 [received]
PHST- 2017/06/20 00:00 [accepted]
PHST- 2017/10/05 06:00 [entrez]
PHST- 2017/10/05 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2017/06/27 00:00 [pmc-release]
AID - 3896034 [pii]
AID - pyx028 [pii]
AID - 10.1093/ijnp/pyx028 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2017 Oct 1;20(10):782-787. doi: 10.1093/ijnp/pyx028.