PMID- 28977527
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20220410
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct 1
TI  - Two Days' Sleep Debt Causes Mood Decline During Resting State Via Diminished 
      Amygdala-Prefrontal Connectivity.
LID - 10.1093/sleep/zsx133 [doi]
AB  - STUDY OBJECTIVES: Sleep debt (SD) has been suggested to evoke emotional 
      instability by diminishing the suppression of the amygdala by the medial 
      prefrontal cortex (MPFC). Here, we investigated how short-term SD affects 
      resting-state functional connectivity between the amygdala and MPFC, 
      self-reported mood, and sleep parameters. METHODS: Eighteen healthy adult men 
      aged 29 +/- 8.24 years participated in a 2-day sleep control session (SC; time in 
      bed [TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each 
      session, resting-state functional magnetic resonance imaging was performed, 
      followed immediately by measuring self-reported mood on the State-Trait Anxiety 
      Inventory-State subscale (STAI-S). RESULTS: STAI-S score was significantly 
      increased, and functional connectivity between the amygdala and MPFC was 
      significantly decreased in SD compared with SC. Significant correlations were 
      observed between reduced rapid eye movement (REM) sleep and reduced left 
      amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced 
      FCL_amg-MPFC and increased STAI-S score in SD compared with SC. CONCLUSIONS: 
      These findings suggest that reduced MPFC functional connectivity of amygdala 
      activity is involved in mood deterioration under SD, and that REM sleep reduction 
      is involved in functional changes in the corresponding brain regions. Having 
      adequate REM sleep may be important for mental health maintenance.
CI  - (c) Sleep Research Society 2017. Published by Oxford University Press on behalf of 
      the Sleep Research Society. All rights reserved. For permissions, please e-mail 
      journals.permissions@oup.com.
FAU - Motomura, Yuki
AU  - Motomura Y
AD  - Department of Psychophysiology, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
AD  - Research Fellow of the Japan Society for the Promotion of Science, 5-3-1 
      Kojimachi, Chiyoda-ku, Tokyo, Japan.
AD  - Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 
      4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
AD  - Department of Human Science, Faculty of Design, Kyushu University, 4-9-1 
      Shiobaru, Minami-ku, Fukuoka, Japan.
FAU - Katsunuma, Ruri
AU  - Katsunuma R
AD  - Department of Psychophysiology, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
AD  - Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 
      4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
FAU - Yoshimura, Michitaka
AU  - Yoshimura M
AD  - Department of Psychophysiology, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
AD  - Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, 
      Shinjuku, Tokyo, Japan.
FAU - Mishima, Kazuo
AU  - Mishima K
AD  - Department of Psychophysiology, National Institute of Mental Health, National 
      Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
MH  - Adult
MH  - Affect/*physiology
MH  - Amygdala/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Personality Inventory
MH  - Prefrontal Cortex/*physiology
MH  - Sleep Deprivation/*physiopathology/*psychology
MH  - Sleep, REM/*physiology
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - anxiety
OT  - functional brain imaging
OT  - functions of REM sleep
OT  - sleep and the brain
OT  - sleep deprivation
EDAT- 2017/10/05 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/10/05 06:00
PHST- 2017/10/05 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/10/05 06:00 [entrez]
AID - 4054186 [pii]
AID - 10.1093/sleep/zsx133 [doi]
PST - ppublish
SO  - Sleep. 2017 Oct 1;40(10). doi: 10.1093/sleep/zsx133.