PMID- 28978176
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 40
DP  - 2017 Sep 15
TI  - Dexmedetomidine attenuates acute paroxysmal sympathetic hyperactivity.
PG  - 69012-69019
LID - 10.18632/oncotarget.16920 [doi]
AB  - We evaluated the curative effect of dexmedetomidine on paroxysmal sympathetic 
      hyperactivity (PSH) in a retrospective study of 72 PSH patients after 
      neurosurgery. Our results showed that dexmedetomidine was superior to propofol 
      for treatment of PSH with respect to: average time needed to reduce paroxysmal 
      hypertension (PH) to <140/90 mmHg (29.03+/-8.86 vs. 42.0+/-14.77 min), average 
      remission time of PH (3.97+/-1.73 vs. 5.65+/-1.51 min), PH remission rate 
      (61.22+/-10.8% vs. 41.52+/-14.15%), PH duration (9.31+/-2.66 vs. 13.05+/-4.19 days), 
      average time for body temperature to return to normal (10.62+/-4.14 vs. 15.31+/-4.58 
      days), average time for heartrate to return to normal (11.34+/-3.90 vs. 15.72+/-4.10 
      days), and average time of respiratory rate below 25 breaths per minute (BPM) 
      (7.00+/-1.74 vs. 15.32+/-5.87 days). Multiple logistic regression analyses showed 
      that dexmedetomidine did not protect against the recurrence of PSH. Age and 
      Glasgow Coma Score were the main factors predicting PSH recurrence. There was no 
      difference in Glasgow Outcome Score (GOS) between the two groups during the 6 
      months of postoperative follow-up (p>0.05). These data suggest dexmedetomidine 
      effectively controls an acute attack of PSH, but it does not improve the 
      long-term prognosis of patients compared with propofol.
FAU - Peng, Yuan
AU  - Peng Y
AD  - Department of Intensive Care Unit and Neurosurgery, The First People's Hospital 
      of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China.
FAU - Zhu, Haifeng
AU  - Zhu H
AD  - Department of Neurosurgery and Medical Oncology, Jiangsu Funing People's 
      Hospital, Funing 224400, P. R. China.
FAU - Chen, Haodong
AU  - Chen H
AD  - Department of Neurosurgery, Liuhe Hospital Affiliated to Medical College of 
      Yangzhou University, Nanjing 211500, P. R. China.
FAU - Zhu, Zijin
AU  - Zhu Z
AD  - Department of Neurosurgery, Anhui Province Wangjiang Hospital, Anhui 246200, P. 
      R. China.
FAU - Zhou, Huahai
AU  - Zhou H
AD  - Department of Neurosurgery, Sihong County People's Hospital, Suqian 223900, P. R. 
      China.
FAU - Zhang, Shuguang
AU  - Zhang S
AD  - Department of Intensive Care Unit and Neurosurgery, The First People's Hospital 
      of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China.
FAU - Gao, Lili
AU  - Gao L
AD  - Department of Neurosurgery and Medical Oncology, Jiangsu Funing People's 
      Hospital, Funing 224400, P. R. China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Intensive Care Unit and Neurosurgery, The First People's Hospital 
      of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China.
FAU - Li, Xiaoliang
AU  - Li X
AD  - Department of Intensive Care Unit and Neurosurgery, The First People's Hospital 
      of Kunshan Affiliated with Jiangsu University, Suzhou 215300, P. R. China.
FAU - Luo, Zhengxiang
AU  - Luo Z
AD  - Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical 
      University, Nanjing 210029, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20170407
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5620316
OTO - NOTNLM
OT  - dexmedetomidine
OT  - paroxysmal sympathetic hyperactivity
OT  - prognosis
OT  - propofol
COIS- CONFLICTS OF INTEREST All authors have declared the sources of research funding 
      for this manuscript and have no financial or other contractual agreements that 
      might cause (or be perceived as causes of) conflicts of interest.
EDAT- 2017/10/06 06:00
MHDA- 2017/10/06 06:01
PMCR- 2017/09/15
CRDT- 2017/10/06 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/10/06 06:00 [entrez]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2017/10/06 06:01 [medline]
PHST- 2017/09/15 00:00 [pmc-release]
AID - 16920 [pii]
AID - 10.18632/oncotarget.16920 [doi]
PST - epublish
SO  - Oncotarget. 2017 Apr 7;8(40):69012-69019. doi: 10.18632/oncotarget.16920. 
      eCollection 2017 Sep 15.