PMID- 28978339
OWN - NLM
STAT- MEDLINE
DCOM- 20180619
LR  - 20191210
IS  - 2047-783X (Electronic)
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 22
IP  - 1
DP  - 2017 Oct 4
TI  - High sensitivity troponin T and I reflect mitral annular plane systolic excursion 
      being assessed by cardiac magnetic resonance imaging.
PG  - 38
LID - 10.1186/s40001-017-0281-x [doi]
LID - 38
AB  - PURPOSE: This study aims to evaluate the association between high sensitivity 
      troponins (hsTn) and mitral annular plane systolic excursion (MAPSE) in patients 
      undergoing cardiac magnetic resonance imaging (cMRI). METHODS: Patients 
      undergoing cMRI were prospectively enrolled. Patients with right ventricular 
      dysfunction (< 50%) were excluded. Blood samples for measurements of hsTn and 
      amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected at the 
      time of cMRI. RESULTS: 84 patients were included. Median left ventricular 
      ejection fraction was 59% (IQR 51-64%). HsTn were correlated inversely with MAPSE 
      within multivariable linear regression models (hsTnI: Beta - 0.19; T - 1.96; 
      p = 0.05; hsTnT: Beta - 0.26; T - 3.26; p = 0.002). HsTn increased significantly 
      according to decreasing stages of impaired MAPSE (p < 0.003). HsTn discriminated 
      patients with impaired MAPSE < 11 mm (hsTnT: AUC = 0.67; p = 0.008; hsTnI: 
      AUC = 0.64; p = 0.03) and < 8 mm (hsTnT: AUC = 0.79; p = 0.0001; hsTnI: 
      AUC = 0.75; p = 0.001) and were still significantly associated in multivariable 
      logistic regression models with impaired MAPSE < 11 mm (hsTnT: OR = 4.71; 
      p = 0.002; hsTnI: OR = 4.22; p = 0.009). CONCLUSIONS: This study demonstrates 
      that hsTn are able to reflect MAPSE being assessed by cMRI.
FAU - Natale, Michele
AU  - Natale M
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Behnes, Michael
AU  - Behnes M
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany. michael.behnes@umm.de.
FAU - Kim, Seung-Hyun
AU  - Kim SH
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Hoffmann, Julia
AU  - Hoffmann J
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Reckord, Nadine
AU  - Reckord N
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Hoffmann, Ursula
AU  - Hoffmann U
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Budjan, Johannes
AU  - Budjan J
AD  - Institute of Clinical Radiology and Nuclear Medicine, Faculty of Medicine 
      Mannheim, University Medical Center Mannheim (UMM), University of Heidelberg, 
      Mannheim, Germany.
FAU - Lang, Siegfried
AU  - Lang S
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
FAU - Bertsch, Thomas
AU  - Bertsch T
AD  - Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, 
      General Hospital Nuremberg, Paracelsus Medical University, Nuremberg, Germany.
FAU - Akin, Ibrahim
AU  - Akin I
AD  - First Department of Medicine, Faculty of Medicine Mannheim, University Medical 
      Center Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, 
      Mannheim, Germany.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20171004
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
EIN - Eur J Med Res. 2018 Feb 19;23 (1):9. PMID: 29458441
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*blood/diagnostic imaging
MH  - Natriuretic Peptide, Brain/blood
MH  - Systole
MH  - Troponin T/*blood
MH  - Ventricular Dysfunction, Left/*blood/diagnostic imaging
PMC - PMC5628434
OTO - NOTNLM
OT  - High sensitivity troponin
OT  - MRI
OT  - Magnetic resonance imaging
OT  - Mitral annular plane systolic excursion
OT  - NT-proBNP
OT  - Natriuretic peptide
OT  - troponin I
OT  - troponin T
EDAT- 2017/10/06 06:00
MHDA- 2018/06/21 06:00
PMCR- 2017/10/04
CRDT- 2017/10/06 06:00
PHST- 2017/03/15 00:00 [received]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/10/06 06:00 [entrez]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2017/10/04 00:00 [pmc-release]
AID - 10.1186/s40001-017-0281-x [pii]
AID - 281 [pii]
AID - 10.1186/s40001-017-0281-x [doi]
PST - epublish
SO  - Eur J Med Res. 2017 Oct 4;22(1):38. doi: 10.1186/s40001-017-0281-x.