PMID- 28979158
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 10
DP  - 2017
TI  - The Central Sensitization Inventory validated and adapted for a Brazilian 
      population: psychometric properties and its relationship with brain-derived 
      neurotrophic factor.
PG  - 2109-2122
LID - 10.2147/JPR.S131479 [doi]
AB  - OBJECTIVES: The primary aim was to assess the psychometric properties (including 
      internal consistency, construct validity, reproducibility, and factor structure) 
      of the Central Sensitization Inventory (CSI), adapted and validated for a 
      Brazilian population (CSI-BP). Additionally, we evaluated the relationship 
      between the CSI-BP and the serum brain-derived neurotrophic factor (BDNF) and 
      determined if the symptoms elicited by the CSI-BP discriminate between subjects 
      who do/do not respond to the conditioned pain modulation (CPM) task, as assessed 
      by change in numeric pain scale (0-10) score. PATIENTS AND METHODS: A 
      cross-sectional study was conducted in a pain clinic in a tertiary teaching 
      hospital. A total of 222 adults with chronic musculoskeletal pain and 63 healthy 
      control subjects completed the CSI-BP and the Brazilian Portuguese 
      pain-catastrophizing scale (BP-PCS). A team of experts translated the CSI 
      according to the international guidelines. Test-retest, item analysis, convergent 
      validity, and factor analysis were performed. Later, a random subsample (n=77) 
      was used to correlate the CSI-BP adjusted index with change in numeric pain-scale 
      score during the CPM task and a BDNF blood sample. RESULTS: The CSI-BP presented 
      strong psychometric properties (test-retest reliability 0.91, Cronbach's alpha=0.91). 
      Confirmatory factor analysis yielded a four-factor structure, supporting the 
      original English version. The CSI-BP adjusted index showed moderate positive 
      correlation with the BP-PCS, and classified more than 80% of patients correctly 
      vs healthy controls. Serum BDNF levels explained 27% of the variation in the 
      CSI-BP adjusted index. Subjects with impairment in the descending modulatory 
      system had higher CSI-BP adjusted index scores than subjects who responded 
      normally to the CPM task: 49.35 (12.1) vs 39.5 (12.33), respectively (P<0.05). 
      CONCLUSION: The CSI-BP was found to be a psychometrically strong and reliable 
      instrument, with primary evidence of validity. Higher scores on the CSI-BP were 
      correlated positively with serum BDNF and with greater dysfunction of the 
      descending pain-modulatory system.
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - Postgraduate Program in Medical Sciences, School of Medicine.
AD  - Pain and Palliative Care Service, Hospital de Clinicas de Porto Alegre.
AD  - Laboratory of Pain and Neuromodulation.
AD  - Surgery Department, School of Medicine, Universidade Federal do Rio Grande do 
      Sul, Porto Alegre.
FAU - Antunes, Luciana C
AU  - Antunes LC
AD  - Postgraduate Program in Medical Sciences, School of Medicine.
FAU - Elkfury, Jessica Lorenzzi
AU  - Elkfury JL
AD  - Postgraduate Program in Medical Sciences, School of Medicine.
FAU - Herbstrith, Evelyn G
AU  - Herbstrith EG
AD  - School of Psychology, Pontificia Universidade Catolica do Rio Grande do Sul.
FAU - Busanello Sipmann, Raquel
AU  - Busanello Sipmann R
AD  - School of Medicine, Universidade Federal do Rio Grande do Sul.
FAU - Souza, Andressa
AU  - Souza A
AD  - Postgraduate Program in Health and Human Development, La Salle University Center, 
      Canoas.
FAU - Torres, Iraci Ls
AU  - Torres IL
AD  - Postgraduate Program in Medical Sciences, School of Medicine.
AD  - Pharmacology Department, Instituto de Ciencias Basicas da Saude, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Souza Dos Santos, Vinicius
AU  - Souza Dos Santos V
AD  - Postgraduate Program in Medical Sciences, School of Medicine.
FAU - Neblett, Randy
AU  - Neblett R
AD  - PRIDE Research Foundation, Dallas, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC5589103
OTO - NOTNLM
OT  - central sensitization
OT  - chronic pain
OT  - conditioned pain modulation
OT  - confirmatory factor analysis
OT  - cross-cultural adaptation
OT  - serum brain-derived neurotrophic factor
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/10/06 06:00
MHDA- 2017/10/06 06:01
PMCR- 2017/09/01
CRDT- 2017/10/06 06:00
PHST- 2017/10/06 06:00 [entrez]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2017/10/06 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - jpr-10-2109 [pii]
AID - 10.2147/JPR.S131479 [doi]
PST - epublish
SO  - J Pain Res. 2017 Sep 1;10:2109-2122. doi: 10.2147/JPR.S131479. eCollection 2017.