PMID- 28979784 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2048-8505 (Print) IS - 2048-8513 (Electronic) IS - 2048-8505 (Linking) VI - 10 IP - 5 DP - 2017 Oct TI - Seventy-seven kidney paired donation transplantations at a single transplant centre in India led to an increase in living donor kidney transplantations in 2015. PG - 709-714 LID - 10.1093/ckj/sfx032 [doi] AB - BACKGROUND: To ascertain the validity of kidney paired donations (KPDs) as an alternative strategy for increasing living donor kidney transplantations (LDKTs) in an LDKT-dominated transplant programme since directed kidney transplantation, ABO-incompatible or crossmatch-positive pairs are not feasible due to costs and infectious complications. METHODS: This was a prospective single-centre study of 77 KPD transplantations (25 two-way, 7 three-way and 1 six-way exchange) from 1 January 2015 to 1 January 2016 of 158 registered donor recipient pairs. During this period, a total of 380 kidney transplantations [71 deceased donor kidney transplantations (DDKTs), 309 LDKTs] were performed. The reasons for opting for KPD were ABO incompatibility (n = 45), sensitization (n = 26) and better matching (n = 6). RESULTS: KPD matching was facilitated in 62% (n = 98) of transplants. In all, 48.7% (n = 77) of the transplants were completed in 2015, whereas 13.3% (n = 21) of the matched patients were to undergo transplant surgery in early 2016 after getting legal permission. The waiting time for KPD was shorter compared with DDKT. The death-censored graft survival and patient survival were 98.7% (n = 76) and 93.5% (n = 72), respectively. In all, 14.2% (n = 11) of patients had acute rejection. Match rates among sensitized (n = 60) and O group patients (n = 62) were 58.3% (n = 35) and 41.9% (n = 26), respectively. Of these, 43.3% (n = 26) and 29% (n = 18) of transplants were completed and 15% (n = 9) and 12.9% (n = 8), respectively, are waiting for legal permission. CONCLUSIONS: LDKT increased by 25% in 1 year in our single-centre KPD programme. Our key to success was the formation of a KPD registry, awareness and active counselling programs and developing a dedicated team. CI - (c) The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. FAU - Kute, Vivek B AU - Kute VB AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Patel, Himanshu V AU - Patel HV AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Shah, Pankaj R AU - Shah PR AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Modi, Pranjal R AU - Modi PR AD - Department of Urology and Transplantation, IKDRC-ITS, Ahmedabad, India. FAU - Shah, Veena R AU - Shah VR AD - Department of Anaesthesia, IKDRC-ITS, Ahmedabad, India. FAU - Rizvi, Sayyed J AU - Rizvi SJ AD - Department of Urology and Transplantation, IKDRC-ITS, Ahmedabad, India. FAU - Pal, Bipin C AU - Pal BC AD - Department of Urology and Transplantation, IKDRC-ITS, Ahmedabad, India. FAU - Shah, Priya S AU - Shah PS AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Varyani, Umesh T AU - Varyani UT AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Wakhare, Pavan S AU - Wakhare PS AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Shinde, Saiprasad G AU - Shinde SG AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Ghodela, Vijay A AU - Ghodela VA AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. FAU - Trivedi, Varsha B AU - Trivedi VB AD - Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohaematology, IKDRC-ITS, Ahmedabad, India. FAU - Patel, Minaxi H AU - Patel MH AD - Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohaematology, IKDRC-ITS, Ahmedabad, India. FAU - Trivedi, Hargovind L AU - Trivedi HL AD - Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, India. LA - eng PT - Journal Article DEP - 20170508 PL - England TA - Clin Kidney J JT - Clinical kidney journal JID - 101579321 PMC - PMC5622902 OTO - NOTNLM OT - developing country OT - kidney paired donation OT - living donor kidney transplantation OT - renal replacement therapy EDAT- 2017/10/06 06:00 MHDA- 2017/10/06 06:01 PMCR- 2017/05/08 CRDT- 2017/10/06 06:00 PHST- 2017/01/03 00:00 [received] PHST- 2017/03/07 00:00 [accepted] PHST- 2017/10/06 06:00 [entrez] PHST- 2017/10/06 06:00 [pubmed] PHST- 2017/10/06 06:01 [medline] PHST- 2017/05/08 00:00 [pmc-release] AID - sfx032 [pii] AID - 10.1093/ckj/sfx032 [doi] PST - ppublish SO - Clin Kidney J. 2017 Oct;10(5):709-714. doi: 10.1093/ckj/sfx032. Epub 2017 May 8.