PMID- 28979809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 7
IP  - 9
DP  - 2017
TI  - MiRNA-107 enhances chemosensitivity to paclitaxel by targeting antiapoptotic 
      factor Bcl-w in non small cell lung cancer.
PG  - 1863-1873
AB  - The aim of this study is to elucidate whether and how miR-107 participates in the 
      modulation of paclitaxel sensitivity in non small cell lung cancer (NSCLC). By 
      qRT-PCR, we found that miR-107 is significantly down-regulated in 
      paclitaxel-resistant A549/Taxol cells compared with corresponding 
      paclitaxel-sensitive counterparts. Overexpression of miR-107 suppresses 
      paclitaxel resistance of A549/Taxol cells through directly inhibiting Bcl-w. 
      Overexpression of miR-107 promotes apoptosis and inhibits proliferation and 
      mobility of A549/Taxol cells under treatment with paclitaxel in vitro. Moreover, 
      miR-107 inhibits in vivo paclitaxel resistance in xenograft model. MiR-107/Bcl-w 
      axis regulates paclitaxel chemoresistance through PI3K-Akt pathway. Our results 
      suggest that up-regulation of miR-107 resensitizes paclitaxel-resistant NSCLC 
      cells by targeting Bcl-w, which reveals a potential mechanism of miR-107 in 
      reversing drug resistance.
FAU - Lu, Chaojing
AU  - Lu C
AD  - Department of Thoracic Surgery, Changhai HospitalShanghai, China.
FAU - Xie, Zhibing
AU  - Xie Z
AD  - Department of Respiratory Medicine, Xiaogan Central Hospital, Wuhan University of 
      Science and TechnologyXiaogan, China.
FAU - Peng, Qingzhen
AU  - Peng Q
AD  - Department of Respiratory Medicine, Xiaogan Central Hospital, Wuhan University of 
      Science and TechnologyXiaogan, China.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC5622221
OTO - NOTNLM
OT  - Bcl-w
OT  - Non small cell lung cancer
OT  - PI3K-Akt pathway
OT  - chemoresistance
OT  - microRNA-107
COIS- None.
EDAT- 2017/10/06 06:00
MHDA- 2017/10/06 06:01
PMCR- 2017/09/01
CRDT- 2017/10/06 06:00
PHST- 2017/07/28 00:00 [received]
PHST- 2017/08/07 00:00 [accepted]
PHST- 2017/10/06 06:00 [entrez]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2017/10/06 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2017 Sep 1;7(9):1863-1873. eCollection 2017.