PMID- 28980219
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20220408
IS  - 2196-5412 (Electronic)
IS  - 2196-5412 (Linking)
VI  - 4
IP  - 4
DP  - 2017 Dec
TI  - Persistent Endocrine-Disrupting Chemicals and Fatty Liver Disease.
PG  - 439-449
LID - 10.1007/s40572-017-0166-8 [doi]
AB  - PURPOSE OF REVIEW: Non-alcoholic fatty liver disease (NAFLD) is the most 
      prominent chronic liver disease in Western countries, affecting approximately 25% 
      of the population worldwide. Sex-specific differences in the development of NAFLD 
      are apparent. While obesity and insulin resistance are major contributors to the 
      increasing prevalence of NAFLD, a growing body of literature suggests that 
      exposure to persistent endocrine-disrupting chemicals (pEDCs) may also play a 
      role. This review summarizes recent (2011 and later) scientific literature 
      investigating exposures to pEDCs, specifically persistent organic pollutants 
      (POPs), and NAFLD, with a focus on sex-specific associations. RECENT FINDINGS: 
      The overwhelming majority of studies were conducted in single-sex animal models 
      and provide biological evidence that exposures to 
      2,3,7,8-tetrachlorodibenzo-p-dioxin polychlorinated biphenyls, and other POPs or 
      POP mixtures are negatively associated with liver health. There were four 
      cross-sectional epidemiological studies in humans that reported associations for 
      several POPs, including polychlorinated biphenyls and perfluorinated chemicals, 
      with elevated liver enzymes. Only one of these studies, using a sample of gastric 
      bypass surgery patients, examined sex-specific associations of POPs and liver 
      enzymes, finding adverse associations among women only. The noticeable lack of 
      studies investigating how differences (i.e., biochemical, physiological, and 
      behavioral) between men and women may influence associations of pEDCs and NAFLD 
      represents a large research gap in environmental health. Sexual dimorphism in 
      metabolic processes throughout the body, including the liver, is established but 
      often overlooked in the designs and analyses of studies. Other factors identified 
      in this review that may also act to modulate associations of environmental 
      chemicals and NAFLD are reproductive status and dietary nutrient intakes, which 
      also remain understudied in the literature. Despite knowledge of sexual 
      dimorphism in the actions of pEDCs, as well as in metabolic processes related to 
      NAFLD development, few experimental or epidemiological studies have investigated 
      sex-dependent associations. Future studies, especially those in humans, should be 
      designed to address this research need. Consideration of other factors, such as 
      reproductive status, dietary intakes, and mixtures of chemicals with varying 
      endocrine-disrupting capabilities, should be explored.
FAU - Deierlein, Andrea L
AU  - Deierlein AL
AD  - College of Global Public Health, New York University, 715/719 Broadway 12th 
      Floor, New York, NY, 10003, USA. ald8@nyu.edu.
FAU - Rock, Sarah
AU  - Rock S
AD  - College of Global Public Health, New York University, 715/719 Broadway 12th 
      Floor, New York, NY, 10003, USA.
FAU - Park, Sally
AU  - Park S
AD  - College of Global Public Health, New York University, 715/719 Broadway 12th 
      Floor, New York, NY, 10003, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Switzerland
TA  - Curr Environ Health Rep
JT  - Current environmental health reports
JID - 101629387
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*adverse effects
MH  - Environmental Pollutants
MH  - Humans
MH  - Non-alcoholic Fatty Liver Disease/*chemically induced
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Sex Characteristics
OTO - NOTNLM
OT  - Fatty liver disease
OT  - Persistent endocrine-disrupting chemicals
OT  - Polychlorinated biphenyl
OT  - TCDD
EDAT- 2017/10/06 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - 10.1007/s40572-017-0166-8 [pii]
AID - 10.1007/s40572-017-0166-8 [doi]
PST - ppublish
SO  - Curr Environ Health Rep. 2017 Dec;4(4):439-449. doi: 10.1007/s40572-017-0166-8.