PMID- 28981141
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20180730
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 47
IP  - 12
DP  - 2017 Dec
TI  - Brain and heart magnetic resonance imaging/spectroscopy in duchenne muscular 
      dystrophy.
LID - 10.1111/eci.12842 [doi]
AB  - Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by 
      progressive and irreversible loss of muscular function. As muscular disease 
      progresses, the repair mechanisms cannot compensate for cellular damage, leading 
      inevitably to necrosis and progressive replacement by fibrous and fatty tissue. 
      Cardiomyopathy and respiratory failure are the main causes of death in DMD. In 
      addition to the well-described muscle and heart disease, cognitive dysfunction 
      affects around 30% of DMD boys. Myocardial fibrosis, assessed by late gadolinium 
      enhancement (LGE), using cardiovascular magnetic resonance imaging (CMR), is an 
      early marker of heart involvement in both DMD patients and female carriers. In 
      parallel, brain MRI identifies smaller total brain volume, smaller grey matter 
      volume, lower white matter fractional anisotropy and higher white matter radial 
      diffusivity in DMD patients. The in vivo brain evaluation of mdx mice, a 
      surrogate animal model of DMD, showed an increased inorganic phosphate 
      (P(i))/phosphocreatine (PCr) and pH. In this paper, we propose a holistic 
      approach using techniques of magnetic resonance imaging, spectroscopy and 
      diffusion tensor imaging as a tool to create a "heart and brain imaging map" in 
      DMD patients that could potentially facilitate the patients' risk stratification 
      and also future research studies in the field.
CI  - (c) 2017 Stichting European Society for Clinical Investigation Journal Foundation.
FAU - Mavrogeni, Sophie
AU  - Mavrogeni S
AUID- ORCID: 0000-0003-1089-7766
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Pons, Roser
AU  - Pons R
AD  - 1st Department of Pediatrics, National and Kapodistrian University of Athens, 
      Aghia Sophia Children's Hospital, Athens, Greece.
FAU - Nikas, Ioannis
AU  - Nikas I
AD  - 1st Department of Pediatrics, National and Kapodistrian University of Athens, 
      Aghia Sophia Children's Hospital, Athens, Greece.
FAU - Papadopoulos, George
AU  - Papadopoulos G
AD  - 1st Department of Pediatrics, National and Kapodistrian University of Athens, 
      Aghia Sophia Children's Hospital, Athens, Greece.
FAU - Verganelakis, Dimitrios A
AU  - Verganelakis DA
AD  - 1st Department of Pediatrics, National and Kapodistrian University of Athens, 
      Aghia Sophia Children's Hospital, Athens, Greece.
FAU - Kolovou, Genovefa
AU  - Kolovou G
AD  - Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Chrousos, George P
AU  - Chrousos GP
AD  - 1st Department of Pediatrics, National and Kapodistrian University of Athens, 
      Aghia Sophia Children's Hospital, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171026
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Phosphates)
RN  - 020IUV4N33 (Phosphocreatine)
SB  - IM
MH  - Animals
MH  - Anisotropy
MH  - Brain/*diagnostic imaging/metabolism/pathology
MH  - Cardiomyopathies/*diagnostic imaging/etiology
MH  - Cognitive Dysfunction/*diagnostic imaging/etiology/metabolism/pathology
MH  - Diffusion Tensor Imaging
MH  - Disease Models, Animal
MH  - Fibrosis
MH  - Gray Matter/diagnostic imaging/pathology
MH  - Heart/*diagnostic imaging
MH  - Heterozygote
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Mice
MH  - Mice, Inbred mdx
MH  - Muscular Dystrophy, Duchenne/complications/*diagnostic imaging/metabolism
MH  - Myocardium/*pathology
MH  - Organ Size
MH  - Phosphates/metabolism
MH  - Phosphocreatine/metabolism
MH  - White Matter/diagnostic imaging/pathology
OTO - NOTNLM
OT  - brain magnetic resonance imaging
OT  - brain magnetic resonance spectroscopy
OT  - cardiovascular magnetic resonance imaging
OT  - diffusion tensor imaging
OT  - duchenne muscular dystrophy
EDAT- 2017/10/06 06:00
MHDA- 2018/07/31 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/03/12 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - 10.1111/eci.12842 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2017 Dec;47(12). doi: 10.1111/eci.12842. Epub 2017 Oct 26.