PMID- 28981143
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 57
IP  - 4
DP  - 2018 Apr
TI  - Effect of very old age on anconeus motor unit loss and compensatory remodelling.
PG  - 659-663
LID - 10.1002/mus.25982 [doi]
AB  - INTRODUCTION: It is not known how the process of compensatory remodeling through 
      collateral reinnervation continues into very old age (>80 years) or whether there 
      is a limit to effective motor unit (MU) reinnervation. Therefore, we explore 
      electrophysiological properties related to motor unit number estimates (MUNEs) in 
      very old participants (79-90 years of age) compared with young controls (25-29 
      years of age). METHODS: Decomposition-enhanced spike-triggered averaging was used 
      to collect surface and intramuscular electromyography information from the 
      anconeus to derive a MUNE. RESULTS: Young participants had a MUNE of  approximately 38 and  approximately 25 
      at 30% and 50% root mean squared maximum voluntary contraction (RMS(MVC) ) with 
      surface motor unit potentials (S-MUPs) of  approximately 145 muV and 236 muV, respectively. Older 
      participants had a MUNE of  approximately 23 and  approximately 16 at 30% and 50% RMS(MVC) with S-MUPs of 
      168 muV and 232 muV, respectively. DISCUSSION: In this muscle, an age limit to 
      successful remodeling through collateral reinnervation, to compensate for the 
      presumed ongoing losses of MUs, may have been surpassed. Muscle Nerve 57: 
      659-663, 2018.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Gilmore, Kevin J
AU  - Gilmore KJ
AD  - School of Kinesiology, Canadian Centre for Activity and Aging, Faculty of Health 
      Sciences, The University of Western Ontario, 1490 Richmond Street London, 
      Ontario, Canada, N6G 2M3.
FAU - Kirk, Eric A
AU  - Kirk EA
AD  - School of Kinesiology, Canadian Centre for Activity and Aging, Faculty of Health 
      Sciences, The University of Western Ontario, 1490 Richmond Street London, 
      Ontario, Canada, N6G 2M3.
FAU - Doherty, Timothy J
AU  - Doherty TJ
AD  - Department of Clinical Neurological Sciences, The University of Western Ontario, 
      London, Ontario, Canada.
AD  - Department of Physical Medicine and Rehabilitation, The University of Western 
      Ontario, London, Ontario, Canada.
FAU - Rice, Charles L
AU  - Rice CL
AD  - School of Kinesiology, Canadian Centre for Activity and Aging, Faculty of Health 
      Sciences, The University of Western Ontario, 1490 Richmond Street London, 
      Ontario, Canada, N6G 2M3.
AD  - Department of Anatomy and Cell Biology, Schulich School of Medicine and 
      Dentistry, The University of Western Ontario, London, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171017
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adult
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Electromyography
MH  - Humans
MH  - Male
MH  - Motor Neurons/*physiology
MH  - Muscle Contraction/*physiology
MH  - Muscle Fibers, Skeletal/*physiology
MH  - Muscle, Skeletal/*innervation
MH  - Neuronal Plasticity/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - DQEMG
OT  - MUNE
OT  - aging
OT  - human
OT  - motor unit
OT  - muscle
EDAT- 2017/10/06 06:00
MHDA- 2019/03/06 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/09/18 00:00 [revised]
PHST- 2017/10/03 00:00 [accepted]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - 10.1002/mus.25982 [doi]
PST - ppublish
SO  - Muscle Nerve. 2018 Apr;57(4):659-663. doi: 10.1002/mus.25982. Epub 2017 Oct 17.