PMID- 28981397
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 27
IP  - 1
DP  - 2019
TI  - Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal 
      Granularity.
PG  - 141-147
LID - 10.1080/09273948.2017.1353104 [doi]
AB  - PURPOSE: To describe multiple evanescent white dot syndrome (MEWDS)-related 
      foveal granularity features on different imaging modalities. METHODS: Clinical 
      and multi-imaging files from five patients affected by MEWDS were reviewed. Each 
      image set included: blue fundus autofluorescence (BAF), near-infrared fundus 
      autofluorescence (NIR-FAF), spectral-domain optical coherence tomography 
      (SD-OCT), fluorescein (FA), and indocyanine green (ICGA) angiography. Foveal 
      granularity features were analyzed and described for each technique at baseline 
      and follow-up. RESULTS: At baseline, 4/5 patients did not show white dots at 
      funduscopic examination, but all subjects demonstrated hypo-fluorescent lesions 
      on ICGA and areas of increased BAF. In all patients, foveal granularity was 
      detectable on NIR-FAF as an irregular hypo-fluorescent area, persisting during 
      follow-up visits. The corresponding SD-OCT scans revealed outer retinal layers' 
      disruption resolving overtime. CONCLUSIONS: Foveal granularity can be the sole 
      presenting sign of MEWDS. NIR-FAF and SD-OCT should be considered as non-invasive 
      investigations in the detection of MEWDS-related foveal granularity.
FAU - Mantovani, Alessandro
AU  - Mantovani A
AUID- ORCID: 0000-0003-3400-1987
AD  - a Ophthalmology Unit , Ospedale Valduce , Como , Italy.
FAU - Invernizzi, Alessandro
AU  - Invernizzi A
AD  - b Eye Clinic, Department of Biomedical and Clinical Science "L. Sacco" , Luigi 
      Sacco Hospital, University of Milan , Milan , Italy.
AD  - c Save Sight Institute , University of Sydney , Sydney , Australia.
FAU - Staurenghi, Giovanni
AU  - Staurenghi G
AD  - b Eye Clinic, Department of Biomedical and Clinical Science "L. Sacco" , Luigi 
      Sacco Hospital, University of Milan , Milan , Italy.
FAU - Herbort, Carl P Jr
AU  - Herbort CP Jr
AD  - d Retinal and inflammatory Eye Diseases , Centre for Ophthalmic Specialized Care 
      (COS), Clinic Montchoisi , Lausanne , Switzerland .
AD  - e Department of Ophthalmology , University of Lausanne , Lausanne , Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20171005
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Coloring Agents/pharmacology
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Fovea Centralis/*pathology
MH  - Fundus Oculi
MH  - Humans
MH  - Indocyanine Green/pharmacology
MH  - Male
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - White Dot Syndromes/*diagnosis
MH  - Young Adult
OTO - NOTNLM
OT  - Autofluorescence
OT  - MEWDS
OT  - fovea granularity
OT  - optical coherence tomography
OT  - uveitis
EDAT- 2017/10/06 06:00
MHDA- 2020/01/07 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - 10.1080/09273948.2017.1353104 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2019;27(1):141-147. doi: 10.1080/09273948.2017.1353104. 
      Epub 2017 Oct 5.