PMID- 28981945
OWN - NLM
STAT- MEDLINE
DCOM- 20180313
LR  - 20180313
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 34
IP  - 5
DP  - 2017 Oct 10
TI  - [Association of HLA-A, -B, -DRB1 alleles and haplotypes with acute lymphoblastic 
      leukemia among ethnic Hans from northern China].
PG  - 737-742
LID - 10.3760/cma.j.issn.1003-9406.2017.05.026 [doi]
AB  - OBJECTIVE: To assess the association of polymorphisms of human leukocyte antigen 
      (HLA)-A, -B, -DRB1 alleles and haplotypes with acute lymphoblastic leukemia (ALL) 
      among ethnic Hans from northern China. METHODS: A total of 170 ALL patients 
      (patient group) and 1241 unrelated healthy bone marrow donors (control group) 
      were genotyped at a high-resolution level using polymerase chain 
      reaction-sequence-based typing (PCR-SBT), sequence specific oligonucleotide 
      probes (SSO) and sequence specific primer (SSP) typing methods. Frequencies of 
      HLA alleles and haplotypes were calculated with Arlequin 3.5.2 software. The 
      distribution of genes and haplotypes were analyzed through a case-control study, 
      and the odd ratio (OR) of ALL was also calculated. RESULTS: By cha-square test 
      and correction, an increased frequency of B*13:01 and B*40:02 among ALL patients 
      was discovered in comparison with the controls (7.35% vs. 4.63%, P=0.030; 2.94% 
      vs. 1.45%, P=0.042), whereas B*35:03 and B*46:01 were less frequent compared with 
      the controls (0.29% vs. 1.69%, P=0.048; 4.41% vs. 7.82%, P=0.025). Although the 
      above discrepancies were not statistically significant by Bonferroni correction, 
      within DRB1*15 group, the frequency of DRB1*15:01 in ALL patients was 
      significantly greater than that of the controls (16.18% vs. 10.19%, Pc'=0.041) 
      and was correlated with ALL (OR=1.70, 95% CI:1.24-2.33). Nineteen haplotypes 
      identified in the ALL patients had a frequency greater than those of the 
      controls. Of these, 11 were absent from the control group and were correlated 
      with ALL. CONCLUSION: The association of HLA-A, -B, -DRB1 polymorphisms with ALL 
      was determined among patients from northern Chinese Hans. The correlation between 
      DRB1*15:01 and ALL suggested that DRB1*15:01 may be a susceptibility gene for ALL 
      with its particular haplotypes.
FAU - Qi, Jun
AU  - Qi J
AD  - High-resolution HLA Typing Laboratory of the Chinese Marrow Donor Program, 
      Shaanxi Blood Center, Xi'an, Shaanxi 710061, China. qijun0802@163.com.
FAU - Chen, Liping
AU  - Chen L
FAU - Wang, Tianju
AU  - Wang T
FAU - Wang, Manni
AU  - Wang M
FAU - Wang, Xiaofang
AU  - Wang X
FAU - Wu, Junhua
AU  - Wu J
FAU - Ye, Shihui
AU  - Ye S
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Young Adult
EDAT- 2017/10/06 06:00
MHDA- 2018/03/14 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/10/06 06:00 [entrez]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2018/03/14 06:00 [medline]
AID - 940634151 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2017.05.026 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Oct 10;34(5):737-742. doi: 
      10.3760/cma.j.issn.1003-9406.2017.05.026.