PMID- 28982029
OWN - NLM
STAT- MEDLINE
DCOM- 20171109
LR  - 20171221
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 512
DP  - 2017 Dec
TI  - Adverse fetal outcomes in pregnant rabbits experimentally infected with rabbit 
      hepatitis E virus.
PG  - 187-193
LID - S0042-6822(17)30329-X [pii]
LID - 10.1016/j.virol.2017.09.020 [doi]
AB  - Hepatitis E virus (HEV) causes severe hepatitis in pregnant women, with 
      associated poor fetal outcomes. To study HEV viral pathogenesis, pregnant rabbits 
      were infected with low- and high-dose rabbit HEV at 2 weeks gestation. HEV was 
      identified in the serum, feces, and liver tissue of infected rabbits, and 
      dose-dependent fetal mortality rates ranging from 67% to 80% were observed. The 
      aspartate transaminase (AST)/alanine transaminase ratio was significantly higher 
      (P < 0.01) in high-dose infected rabbits than low-dose infected and negative 
      control rabbits 14 days post infection (dpi). Tumor necrosis factor-alpha (TNF-alpha) was 
      significantly higher in low-dose (P < 0.01) and high-dose infected rabbits (P < 
      0.001) than in negative controls 7 dpi. High-dose HEV-infected rabbits produced 
      significantly more interferon-gamma (IFN-gamma; P < 0.05) than negative control rabbits 
      at 7 and 14 dpi. High levels of AST, TNF-alpha, and IFN-gamma may substantially influence 
      adverse fetal outcomes in pregnant rabbits infected with high-dose HEV.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ahn, Hee-Seop
AU  - Ahn HS
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Han, Sang-Hoon
AU  - Han SH
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Kim, Yong-Hyun
AU  - Kim YH
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Park, Byung-Joo
AU  - Park BJ
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Kim, Dong-Hwi
AU  - Kim DH
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Lee, Joong-Bok
AU  - Lee JB
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Park, Seung-Yong
AU  - Park SY
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Song, Chang-Seon
AU  - Song CS
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Lee, Sang-Won
AU  - Lee SW
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
FAU - Choi, Changsun
AU  - Choi C
AD  - Department of Food and Nutrition, School of Food Science and Technology, 
      Chung-Ang University, Ansung 17546, Republic of Korea.
FAU - Myoung, Jinjong
AU  - Myoung J
AD  - Korea Zoonosis Research Institute, Chonbuk National University, Jeonju 54896, 
      Republic of Korea.
FAU - Choi, In-Soo
AU  - Choi IS
AD  - Department of Infectious Diseases, College of Veterinary Medicine, Konkuk 
      University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. 
      Electronic address: ischoi@konkuk.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171002
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cytokines/genetics/metabolism
MH  - Female
MH  - Gene Expression Regulation/immunology
MH  - Hepatitis E/pathology/*virology
MH  - Hepatitis E virus/*classification/pathogenicity
MH  - Hepatitis, Viral, Animal/*pathology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/pathology/*virology
MH  - Rabbits/*abnormalities
MH  - Specific Pathogen-Free Organisms
MH  - Virus Replication
OTO - NOTNLM
OT  - Aspartate transaminase
OT  - Fetal mortality
OT  - Hepatitis E virus
OT  - Interferon-gamma
OT  - Pregnancy
OT  - Rabbit
OT  - Tumor necrosis factor-alpha
EDAT- 2017/10/06 06:00
MHDA- 2017/11/10 06:00
CRDT- 2017/10/06 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/08/29 00:00 [revised]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/10/06 06:00 [pubmed]
PHST- 2017/11/10 06:00 [medline]
PHST- 2017/10/06 06:00 [entrez]
AID - S0042-6822(17)30329-X [pii]
AID - 10.1016/j.virol.2017.09.020 [doi]
PST - ppublish
SO  - Virology. 2017 Dec;512:187-193. doi: 10.1016/j.virol.2017.09.020. Epub 2017 Oct 
      2.