PMID- 28982330
OWN - NLM
STAT- MEDLINE
DCOM- 20190508
LR  - 20190508
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 14
IP  - 4
DP  - 2017
TI  - Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and 
      Nitrites in Patients with Acute Ischemic Stroke.
PG  - 338-346
LID - 10.2174/1567202614666171005122925 [doi]
AB  - BACKGROUND: Acute Ischemic Stroke (AIS) represents an economic challenge for 
      health systems all over the globe. Changes of neuroactive steroids have been 
      found in different neurological diseases. We have previously demonstrated that 
      old patients with AIS show changes of plasma cortisol and estradiol 
      concentrations, in that increased steroid levels are associated with a 
      deterioration of neurological status and a worse cognitive decline. OBJECTIVE: 
      The present study assessed in patients with AIS if changes of behavior, 
      Brain-Derived Neurotrophic Factor (BDNF) and Nitrites (NO-2) bear a relationship 
      with the degree of hypercortisolism. METHODS: We recruited patients hospitalized 
      within the first 24 hours of AIS. Subjects were divided into two groups, each one 
      composed of 40 control subjects and 40 AIS patients, including men and women. The 
      neurological condition was assessed using the National Institute of Health Stroke 
      Scale (NIHSS) and the cognitive status with the Montreal Cognitive Assessment 
      (MoCA). The emotional status was evaluated using the Montgomery-Asberg Depression 
      Rating Scale (MADRS), whereas the Modified Rankin Scale (MRS) was used to 
      determine the functional condition. BDNF and NO-2 plasma levels were measured by 
      ELISA and the Griess reaction method, respectively. RESULTS: We found that in AIS 
      patients, increased plasma cortisol was negatively correlated with plasma BDNF 
      and NO-2 levels, neurological condition, cognition, functional responses and 
      emotional status, suggesting a relationship between the declines of clinical, 
      behavioral and blood parameters with stress-induced cortisol elevation. 
      CONCLUSION: Nitrites and BDNF may represent potential biomarkers for cortisol 
      negative effects on the area of cerebral ischemia and penumbra, potentiating 
      ischemic cell damage.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Casas, S
AU  - Casas S
AD  - Servicio de Neurologia, Hospital Militar Central-H Grl 601-  Cir My Dr. Cosme 
      Argerich -, Buenos Aires, Argentina.
FAU - Perez, A F
AU  - Perez AF
AD  - Servicio de Neurologia, Hospital Militar Central-H Grl 601-  Cir My Dr. Cosme 
      Argerich -, Buenos Aires, Argentina.
FAU - Mattiazzi, M
AU  - Mattiazzi M
AD  - Servicio de Neurologia, Hospital Militar Central-H Grl 601-  Cir My Dr. Cosme 
      Argerich -, Buenos Aires, Argentina.
FAU - Lopez, J
AU  - Lopez J
AD  - Servicio de Neurologia, Hospital Militar Central-H Grl 601-  Cir My Dr. Cosme 
      Argerich -, Buenos Aires, Argentina.
FAU - Folgueira, A
AU  - Folgueira A
AD  - Servicio de Neurologia, Hospital Militar Central-H Grl 601-  Cir My Dr. Cosme 
      Argerich -, Buenos Aires, Argentina.
FAU - Gargiulo-Monachelli, G M
AU  - Gargiulo-Monachelli GM
AD  - Laboratorio de Bioquimica Neuroendocrina, Instituto de Biologia y Medicina 
      Experimental (IBYME)-CONICET, Buenos Aires, Argentina.
FAU - Gonzalez Deniselle, M C
AU  - Gonzalez Deniselle MC
AD  - Laboratorio de Bioquimica Neuroendocrina, Instituto de Biologia y Medicina 
      Experimental (IBYME)-CONICET, Buenos Aires, Argentina.
FAU - De Nicola, A F
AU  - De Nicola AF
AD  - Laboratorio de Bioquimica Neuroendocrina, Instituto de Biologia y Medicina 
      Experimental (IBYME)-CONICET, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nitrites)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain Ischemia/*blood/diagnosis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Male
MH  - Middle Aged
MH  - Nitrites/*blood
MH  - Random Allocation
MH  - Stroke/*blood/diagnosis
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - brain-derived neurotrophic factor
OT  - cortisol
OT  - neurological outcomes
OT  - nitrites
OT  - patients
EDAT- 2017/10/07 06:00
MHDA- 2019/05/09 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2017/09/23 00:00 [revised]
PHST- 2017/09/24 00:00 [accepted]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2019/05/09 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
AID - CNR-EPUB-86216 [pii]
AID - 10.2174/1567202614666171005122925 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2017;14(4):338-346. doi: 10.2174/1567202614666171005122925.