PMID- 2898273
OWN - NLM
STAT- MEDLINE
DCOM- 19880803
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 447
IP  - 1
DP  - 1988 Apr 26
TI  - Orally administered MDMA causes a long-term depletion of serotonin in rat brain.
PG  - 141-4
AB  - Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when 
      administered subcutaneously, is toxic to central serotonergic neurons in rats. 
      Because humans typically self-administer this drug orally, we compared this route 
      to the s.c. route of administration. Orally administered MDMA produced a 
      dose-related depletion of serotonin comparable to that produced by the s.c. 
      route. These findings suggest that MDMA, when given orally, retains it neurotoxic 
      activity and that humans using MDMA may be at risk for developing a persistent 
      depletion of brain serotonin.
FAU - Finnegan, K T
AU  - Finnegan KT
AD  - Institute for Medical Research, San Jose, CA 95128.
FAU - Ricaurte, G A
AU  - Ricaurte GA
FAU - Ritchie, L D
AU  - Ritchie LD
FAU - Irwin, I
AU  - Irwin I
FAU - Peroutka, S J
AU  - Peroutka SJ
FAU - Langston, J W
AU  - Langston JW
LA  - eng
GR  - NS 23560-01/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amphetamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/analogs & 
      derivatives/*pharmacology
MH  - Administration, Oral
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Injections, Subcutaneous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Serotonin/*metabolism
MH  - Time Factors
EDAT- 1988/04/26 00:00
MHDA- 1988/04/26 00:01
CRDT- 1988/04/26 00:00
PHST- 1988/04/26 00:00 [pubmed]
PHST- 1988/04/26 00:01 [medline]
PHST- 1988/04/26 00:00 [entrez]
AID - 0006-8993(88)90974-2 [pii]
AID - 10.1016/0006-8993(88)90974-2 [doi]
PST - ppublish
SO  - Brain Res. 1988 Apr 26;447(1):141-4. doi: 10.1016/0006-8993(88)90974-2.