PMID- 28983094
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20240327
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 31
IP  - 10
DP  - 2017 Oct
TI  - Application of OCT-angiography to characterise the evolution of chorioretinal 
      lesions in acute posterior multifocal placoid pigment epitheliopathy.
PG  - 1399-1408
LID - 10.1038/eye.2017.180 [doi]
AB  - PurposeThe aim of this study was to determine a sequence of structural changes in 
      acute posterior multifocal placoid pigment epitheliopathy (APMPPE) using optical 
      coherence tomography-angiography (OCT-A) and comparing with other imaging 
      modalities.Patients and methodsPatients with a new diagnosis of acute-onset 
      APMPPE referred to a regional specialist centre from October 2015 to October 2016 
      were included. Multimodal imaging employed on all patients from diagnosis 
      included the following: fundus fluorescein angiography, indocyanine green 
      angiography, fundus autofluorescence, spectral domain-OCT (SD-OCT), and OCT-A. 
      All non-invasive imaging processes were repeated during follow-up.ResultsTen eyes 
      of five patients were included in the study, three males and two females, with a 
      mean age of 26.2 years (range: 21-32) and a mean follow-up of 6.4 months (range: 
      2.6-13.3). All patients presented with bilateral disease and macular involving 
      lesions. OCT-A imaging of the choriocapillaris was supportive of hypoperfusion at 
      the site of APMPPE lesions during the acute phase of this condition with 
      normalisation of choroidal vasculature during follow-up. Multimodal imaging 
      consistently highlighted four sequential phases from presentation to resolution 
      of active disease.ConclusionsMultimodal imaging in patients with APMPPE in acute 
      and long-term follow-up demonstrates a reversible choroidal hypoperfusion 
      supporting the primary inciting pathology as a choriocapillaritis. The evolution 
      shows resolution of the ischaemia through a defined sequence that results in 
      persistent changes at the level of the retinal pigment epithelium and outer 
      retina. OCT-A was able to detect preclinical changes and chart resolution at the 
      level of the choriocapillaris.
FAU - Burke, T R
AU  - Burke TR
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
FAU - Chu, C J
AU  - Chu CJ
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
AD  - School of Clinical Sciences, Faculty of Medicine and Dentistry, University of 
      Bristol, Bristol, UK.
FAU - Salvatore, S
AU  - Salvatore S
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
FAU - Bailey, C
AU  - Bailey C
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
FAU - Dick, A D
AU  - Dick AD
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
AD  - School of Clinical Sciences, Faculty of Medicine and Dentistry, University of 
      Bristol, Bristol, UK.
AD  - National Institute for Health Research Biomedical Research Centre at Moorfields 
      Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
FAU - Lee, R W J
AU  - Lee RWJ
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
AD  - School of Clinical Sciences, Faculty of Medicine and Dentistry, University of 
      Bristol, Bristol, UK.
AD  - National Institute for Health Research Biomedical Research Centre at Moorfields 
      Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK.
FAU - Ross, A H
AU  - Ross AH
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
FAU - Carreno, E
AU  - Carreno E
AD  - Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, 
      UK.
CN  - Medscape
LA  - eng
GR  - MOOBRC-2012-1/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20171006
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Choroiditis/*diagnosis/physiopathology
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Multifocal Choroiditis
MH  - *Multimodal Imaging
MH  - Posterior Eye Segment/*pathology
MH  - Reproducibility of Results
MH  - Retinal Pigment Epithelium/pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Young Adult
PMC - PMC5639187
MID - EMS73052
COIS- The authors declare no conflict of interest.
EDAT- 2017/10/07 06:00
MHDA- 2018/02/24 06:00
PMCR- 2018/10/01
CRDT- 2017/10/07 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/06/06 00:00 [accepted]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - eye2017180 [pii]
AID - 10.1038/eye.2017.180 [doi]
PST - ppublish
SO  - Eye (Lond). 2017 Oct;31(10):1399-1408. doi: 10.1038/eye.2017.180. Epub 2017 Oct 
      6.