PMID- 28983807
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20181113
IS  - 1865-0341 (Electronic)
IS  - 1865-0333 (Linking)
VI  - 10
IP  - 4
DP  - 2017 Dec
TI  - Relationship between tumor volume and quantitative values calculated using 
      two-dimensional bone scan images.
PG  - 496-506
LID - 10.1007/s12194-017-0423-4 [doi]
AB  - The bone scan index (BSI) is calculated from a whole-body bone scan image; it 
      shows the tumor burden in bone as a percentage of total skeletal mass. It has 
      been used to determine the prognosis and to assess treatment effects; however, 
      little has been reported on whether the BSI calculated using a two-dimensional 
      image can accurately evaluate the three-dimensional spread in tumor volume. We 
      investigated the relationship between tumor volume and BSI using Monte Carlo 
      simulation (MCS). We simulated a gamma camera and constructed a voxel phantom 
      based on an anthropomorphic phantom computed tomography (CT) image and gamma rays 
      emitted from each part according to technetium-99m-labeled methylene 
      diphosphonate ((99m)Tc-MDP) uptake (bone 1, soft tissue 0.2, tumor 2-32). We 
      constructed bone scan images from the obtained counts and analyzed them using the 
      BSI calculation software. The BSI increased with increased tumor uptake (two- to 
      32-fold). However, there was not always a significant difference between change 
      in BSI and tumor uptake of eight times or greater than that of bone. When BSI was 
      calculated with a tumor having an uptake of four-to-eight times higher than that 
      of bone, the BSI was consistent with tumor volume, but decreased to about half 
      the tumor volume when tumors were in the thoracic spine (Th-spine) segment. The 
      BSI can be a good indicator of tumor volume in most segments, even though it is 
      affected by the tumor's (99m)Tc-MDP uptake. Nevertheless, values calculated from 
      the Th-spine should be interpreted carefully.
FAU - Hosokawa, Shota
AU  - Hosokawa S
AD  - Graduate School of Human Health Sciences, Department of Radiological Sciences, 
      Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo, 116-8551, 
      Japan.
AD  - Graduate School of Health Sciences, Department of Radiation Science, Hirosaki 
      University, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564, Japan.
FAU - Inoue, Kazumasa
AU  - Inoue K
AD  - Graduate School of Human Health Sciences, Department of Radiological Sciences, 
      Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo, 116-8551, 
      Japan. kzminoue@tmu.ac.jp.
FAU - Takahashi, Yasuyuki
AU  - Takahashi Y
AD  - Graduate School of Health Sciences, Department of Radiation Science, Hirosaki 
      University, 66-1 Hon-cho, Hirosaki, Aomori, 036-8564, Japan.
FAU - Kawakami, Kazunori
AU  - Kawakami K
AD  - FUJIFILM RI Pharma Co., Ltd., 2-14-1 Kyobashi, Chuo-ku, Tokyo, 104-0031, Japan.
FAU - Kano, Daisuke
AU  - Kano D
AD  - Department of Pharmacy, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 
      Kashiwa, Chiba, 277-8577, Japan.
AD  - Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 
      Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
FAU - Nakagami, Yoshihiro
AU  - Nakagami Y
AD  - Department of Diagnostic Radiology, National Cancer Center Hospital East, 6-5-1 
      Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
AD  - Department of Radiology, Yokohama City University School of Medicine, 3-9 
      Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
FAU - Fukushi, Masahiro
AU  - Fukushi M
AD  - Graduate School of Human Health Sciences, Department of Radiological Sciences, 
      Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo, 116-8551, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20171005
PL  - Japan
TA  - Radiol Phys Technol
JT  - Radiological physics and technology
JID - 101467995
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
SB  - IM
MH  - Bone Neoplasms/diagnostic imaging/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - *Monte Carlo Method
MH  - *Phantoms, Imaging
MH  - Radionuclide Imaging/*methods
MH  - Spinal Neoplasms/diagnostic imaging/*pathology
MH  - Technetium Tc 99m Medronate
MH  - Tumor Burden
MH  - Whole Body Imaging/*methods
OTO - NOTNLM
OT  - Bone scan index
OT  - Bone scintigraphy
OT  - Computer-aided diagnosis
OT  - Geant4
OT  - Monte Carlo simulation
EDAT- 2017/10/07 06:00
MHDA- 2018/08/01 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/09/19 00:00 [revised]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
AID - 10.1007/s12194-017-0423-4 [pii]
AID - 10.1007/s12194-017-0423-4 [doi]
PST - ppublish
SO  - Radiol Phys Technol. 2017 Dec;10(4):496-506. doi: 10.1007/s12194-017-0423-4. Epub 
      2017 Oct 5.