PMID- 28983964
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180714
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 66
IP  - 1
DP  - 2018 Jan
TI  - Dopamine cross-reacts with adrenoreceptors in cortical astrocytes to induce BDNF 
      expression, CREB signaling and morphological transformation.
PG  - 206-216
LID - 10.1002/glia.23238 [doi]
AB  - Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat 
      cortical astrocytes by catecholamines norepinephrine and dopamine as well as 
      selective alpha1 and beta adrenergic agonists. However, it has remained unknown which 
      receptors mediate dopamine-induced BDNF upregulation in astrocytes. Here, we 
      demonstrate that beta adrenoreceptors are the main mediators of this effect in 
      cultured cortical astrocytes, while alpha1 adrenoreceptors and D1 dopamine receptors 
      contribute to a lesser extent. We show that in cortical astrocytes BDNF exon IV 
      and exon VI containing mRNAs are induced by dopamine and norepinephrine via 
      CREB-dependent signaling and that this regulation is mediated by a mechanism that 
      is distinct from activity-dependent CREB-mediated activation of BDNF 
      transcription in neurons. We also show that regulation of BDNF promoters IV and 
      VI by catecholamines requires a distal regulatory element in the BDNF locus. 
      Finally, we demonstrate that dopamine-induced astrocyte stellation and induction 
      of CREB signaling are mediated by cross-reaction of dopamine with beta 
      adrenoreceptors.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Koppel, Indrek
AU  - Koppel I
AUID- ORCID: 0000-0002-9338-8889
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Jaanson, Kaur
AU  - Jaanson K
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Klasche, Airi
AU  - Klasche A
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Tuvikene, Jurgen
AU  - Tuvikene J
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Tiirik, Tonis
AU  - Tiirik T
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Parn, Angela
AU  - Parn A
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
FAU - Timmusk, Tonis
AU  - Timmusk T
AD  - Institute of Chemistry and Biotechnology, Tallinn University of Technology, 
      Tallinn, 12618, Estonia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171006
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/*cytology
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*metabolism
MH  - Dopamine/pharmacology
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - HEK293 Cells
MH  - Humans
MH  - Neurons/drug effects/metabolism
MH  - Norepinephrine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adrenergic/genetics/*metabolism
MH  - Receptors, Dopamine/*metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Time Factors
MH  - Transcriptional Activation
OTO - NOTNLM
OT  - BAC
OT  - BDNF
OT  - CREB
OT  - catecholamine
EDAT- 2017/10/07 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/09/09 00:00 [revised]
PHST- 2017/09/11 00:00 [accepted]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
AID - 10.1002/glia.23238 [doi]
PST - ppublish
SO  - Glia. 2018 Jan;66(1):206-216. doi: 10.1002/glia.23238. Epub 2017 Oct 6.