PMID- 28984138
OWN - NLM
STAT- MEDLINE
DCOM- 20190717
LR  - 20240404
IS  - 1938-2731 (Electronic)
IS  - 1533-3175 (Print)
IS  - 1533-3175 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Feb
TI  - Val66Met Polymorphism in BDNF Has No Sexual and APOE epsilon4 Status-Based Dimorphic 
      Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated 
      Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts.
PG  - 55-63
LID - 10.1177/1533317517733037 [doi]
AB  - Some studies showed that Val66Met polymorphism of brain-derived neurotrophic 
      factor (BDNF) conveys susceptibility to Alzheimer's disease (AD) in females only. 
      However, the confounding effects of some risk factors for AD were omitted in 
      these studies. The aim of this meta-analysis comprising 19 604 patients with AD 
      and 26 333 controls was to reexamine the association between Val66Met and AD by 
      conditioning the effects of age, sex, and/or apolipoprotein E ( APOE) epsilon4 status. 
      In agreement with the previous meta-analysis, Val66Met was associated with AD in 
      females without confounding adjustment (odds ratio [OR], 1.08; 95% confidence 
      interval [CI], 1.03-1.14; P = .003). Nevertheless, after adjusting for age and 
      APOE epsilon4 status, Val66Met was not associated with AD in females (OR, 1.02; 95% CI, 
      0.94-1.11; P = .57). This comprehensive meta-analysis with the largest sample 
      size demonstrated no association could be observed between Val66Met and AD in 
      general or by dividing samples based on sex or APOE epsilon4.
FAU - Zhao, Qingnan
AU  - Zhao Q
AD  - 1 Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, People's Republic of China.
AD  - 2 Department of Pediatrics, The University of Texas MD Anderson Cancer center, 
      Houston, TX, USA.
FAU - Shen, Yaqi
AU  - Shen Y
AD  - 3 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong 
      University, Shanghai, People's Republic of China.
FAU - Zhao, Yanli
AU  - Zhao Y
AD  - 4 Basic Medical Sciences Department, Qinghai University, Xining, Qinghai, 
      People's Republic of China.
FAU - Si, Lining
AU  - Si L
AD  - 5 Department of Critical Care Medicine, Affiliated Hospital of Qinghai 
      University, Xining, Qinghai, People's Republic of China.
FAU - Jiang, Shan
AU  - Jiang S
AD  - 1 Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, People's Republic of China.
AD  - 6 Department of Psychiatry, The University of Illinois at Chicago, Chicago, IL, 
      USA.
AD  - 7 Department of Psychiatry, Washington University School of Medicine, St Louis, 
      MO, USA.
FAU - Qiu, Yu
AU  - Qiu Y
AD  - 1 Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, People's Republic of China.
CN  - Alzheimer's Disease Neuroimaging Initiative (ADNI)
LA  - eng
GR  - P50 AG005142/AG/NIA NIH HHS/United States
GR  - P50 AG047266/AG/NIA NIH HHS/United States
GR  - P30 AG010161/AG/NIA NIH HHS/United States
GR  - R01 NS080820/NS/NINDS NIH HHS/United States
GR  - P30 AG028383/AG/NIA NIH HHS/United States
GR  - P50 AG033514/AG/NIA NIH HHS/United States
GR  - R01 AG015819/AG/NIA NIH HHS/United States
GR  - P30 AG013854/AG/NIA NIH HHS/United States
GR  - K01 AG030514/AG/NIA NIH HHS/United States
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - P50 AG023501/AG/NIA NIH HHS/United States
GR  - U01 HG006375/HG/NHGRI NIH HHS/United States
GR  - RC2 AG036528/AG/NIA NIH HHS/United States
GR  - R01 AG009029/AG/NIA NIH HHS/United States
GR  - P50 AG005131/AG/NIA NIH HHS/United States
GR  - P30 AG010133/AG/NIA NIH HHS/United States
GR  - U24 AG021886/AG/NIA NIH HHS/United States
GR  - P50 AG016574/AG/NIA NIH HHS/United States
GR  - P50 AG005146/AG/NIA NIH HHS/United States
GR  - R01 AG019085/AG/NIA NIH HHS/United States
GR  - U01 AG032984/AG/NIA NIH HHS/United States
GR  - U01 HG008657/HG/NHGRI NIH HHS/United States
GR  - U01 AG024904/AG/NIA NIH HHS/United States
GR  - P30 AG035982/AG/NIA NIH HHS/United States
GR  - P50 AG008702/AG/NIA NIH HHS/United States
GR  - U01 AG016976/AG/NIA NIH HHS/United States
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
GR  - P30 AG013846/AG/NIA NIH HHS/United States
GR  - P01 AG026276/AG/NIA NIH HHS/United States
GR  - R01 AG017917/AG/NIA NIH HHS/United States
GR  - P50 AG047270/AG/NIA NIH HHS/United States
GR  - R01 AG026390/AG/NIA NIH HHS/United States
GR  - R01 AG028786/AG/NIA NIH HHS/United States
GR  - P50 AG005136/AG/NIA NIH HHS/United States
GR  - P30 AG012300/AG/NIA NIH HHS/United States
GR  - RF1 AG051504/AG/NIA NIH HHS/United States
GR  - P50 AG016573/AG/NIA NIH HHS/United States
GR  - U24 AG041689/AG/NIA NIH HHS/United States
GR  - P50 AG016570/AG/NIA NIH HHS/United States
GR  - P50 AG005134/AG/NIA NIH HHS/United States
GR  - P30 AG008017/AG/NIA NIH HHS/United States
GR  - P50 AG025688/AG/NIA NIH HHS/United States
GR  - R01 AG032990/AG/NIA NIH HHS/United States
GR  - U24 AG026395/AG/NIA NIH HHS/United States
GR  - P50 AG005133/AG/NIA NIH HHS/United States
GR  - P01 AG002219/AG/NIA NIH HHS/United States
GR  - U01 AG006781/AG/NIA NIH HHS/United States
GR  - R01 AG041797/AG/NIA NIH HHS/United States
GR  - R01 AG041232/AG/NIA NIH HHS/United States
GR  - P50 AG005138/AG/NIA NIH HHS/United States
GR  - U01 AG046139/AG/NIA NIH HHS/United States
GR  - R01 AG027944/AG/NIA NIH HHS/United States
GR  - R01 AG025259/AG/NIA NIH HHS/United States
GR  - R01 AG030653/AG/NIA NIH HHS/United States
GR  - P50 AG047366/AG/NIA NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
GR  - P30 AG010129/AG/NIA NIH HHS/United States
GR  - P30 AG019610/AG/NIA NIH HHS/United States
GR  - R01 AG041718/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20171006
PL  - United States
TA  - Am J Alzheimers Dis Other Demen
JT  - American journal of Alzheimer's disease and other dementias
JID - 101082834
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Alleles
MH  - Alzheimer Disease/*genetics
MH  - Apolipoprotein E4/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Risk Factors
PMC - PMC10852485
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Val66Met polymorphism
OT  - brain-derived neurotrophic factor
OT  - high-throughput genotyping
OT  - meta-analysis
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2017/10/07 06:00
MHDA- 2019/07/18 06:00
PMCR- 2018/02/01
CRDT- 2017/10/07 06:00
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2019/07/18 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1177_1533317517733037 [pii]
AID - 10.1177/1533317517733037 [doi]
PST - ppublish
SO  - Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):55-63. doi: 
      10.1177/1533317517733037. Epub 2017 Oct 6.