PMID- 28984621
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20240316
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Print)
IS  - 0922-6028 (Linking)
VI  - 35
IP  - 5
DP  - 2017
TI  - The effects of exercise on cognitive function and brain plasticity - a 
      feasibility trial.
PG  - 547-556
LID - 10.3233/RNN-170758 [doi]
AB  - BACKGROUND: Exercise-mediated cognitive improvements can be at least partly 
      attributed to neuroplastic changes in the nervous system, and may be influenced 
      by the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) 
      gene. Transcranial magnetic stimulation (TMS) can be used to assess mechanisms of 
      plasticity in humans noninvasively. OBJECTIVES: To assess the feasibility of 
      evaluating the effects of short-term regular exercise on cognitive performance, 
      and to evaluate the relationship between these effects, TMS measures of 
      plasticity, and BDNF Met carrier status in young healthy sedentary adults. 
      METHODS: Of the 19 participants who enrolled in the study, 14 sedentary adults 
      (12 females, age mean+/-SD, 27+/-12.3 yr), with less than two sessions of physical 
      exercise in the preceding 2 months, completed an aerobic exercise regimen 
      including four 30-min daily sessions per week for 4 weeks (for a total of 16 
      sessions) delivered at 55-64% of age-predicted maximal heart rate. Prior to and 
      following the exercise regimen, participants performed a neuropsychological test 
      battery and an intermittent theta-burst TMS plasticity protocol. RESULTS: All 
      participants completed the various measures and adhered to the exercise regimen. 
      There were no complications and the results obtained were reliable. The 
      feasibility of the approach is thus well established. Between-group comparisons 
      of pre-post change revealed trends toward increased performance on the Stroop and 
      faster reaction times in the CPT detectability in the Val66Val subgroup (p = 0.07 
      and p = 0.08), and a reduction in TBS-induced modulation of TMS responses in Met 
      carriers (p = 0.07). CONCLUSION: Acute exercise interventions in sedentary adults 
      can be meaningfully conducted along with cognitive and neurophysiologic measures 
      to assess behavioral and neurobiological effects and assessment of BDNF 
      polymorphism. TMS measures of plasticity can be used to evaluate the effects of 
      exercise on brain plasticity, and relate them to neuropsychological measures of 
      cognition.
FAU - Gomes-Osman, Joyce
AU  - Gomes-Osman J
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive 
      Neurology, Department of Neurology, Beth Israel Deaconess Medical Center - 
      Harvard Medical School, Boston, MA, USA.
AD  - Department of Physical Therapy, University of Miami Miller School of Medicine, 
      Coral Gables, FL, USA.
FAU - Cabral, Danylo F
AU  - Cabral DF
AD  - Department of Physical Therapy, University of Miami Miller School of Medicine, 
      Coral Gables, FL, USA.
FAU - Hinchman, Carrie
AU  - Hinchman C
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive 
      Neurology, Department of Neurology, Beth Israel Deaconess Medical Center - 
      Harvard Medical School, Boston, MA, USA.
FAU - Jannati, Ali
AU  - Jannati A
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive 
      Neurology, Department of Neurology, Beth Israel Deaconess Medical Center - 
      Harvard Medical School, Boston, MA, USA.
FAU - Morris, Timothy P
AU  - Morris TP
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive 
      Neurology, Department of Neurology, Beth Israel Deaconess Medical Center - 
      Harvard Medical School, Boston, MA, USA.
FAU - Pascual-Leone, Alvaro
AU  - Pascual-Leone A
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive 
      Neurology, Department of Neurology, Beth Israel Deaconess Medical Center - 
      Harvard Medical School, Boston, MA, USA.
AD  - Institut Guttman de Neurorehabilitacio, Universitat Autonoma de Barcelona, 
      Badalona, Barcelona, Spain.
LA  - eng
GR  - R01 MH100186/MH/NIMH NIH HHS/United States
GR  - R21 NS085491/NS/NINDS NIH HHS/United States
GR  - R01 NS073601/NS/NINDS NIH HHS/United States
GR  - R21 MH099196/MH/NIMH NIH HHS/United States
GR  - R01 HD069776/HD/NICHD NIH HHS/United States
GR  - R21 HD077616/HD/NICHD NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Acute-Phase Proteins
MH  - Adult
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Cognition/*physiology
MH  - Exercise/*physiology/*psychology
MH  - Feasibility Studies
MH  - Female
MH  - Genotyping Techniques
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Neuropsychological Tests
MH  - Pilot Projects
MH  - Polymorphism, Genetic
MH  - Sedentary Behavior
MH  - Transcranial Magnetic Stimulation
PMC - PMC5839170
MID - NIHMS946099
OTO - NOTNLM
OT  - Aerobic exercise
OT  - BDNF
OT  - cognition
OT  - iTBS
OT  - plasticity
OT  - transcranial magnetic stimulation
COIS- Conflict of interests statement The authors declare no competing interest.
EDAT- 2017/10/07 06:00
MHDA- 2018/06/05 06:00
PMCR- 2018/03/06
CRDT- 2017/10/07 06:00
PHST- 2017/10/07 06:00 [entrez]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2018/03/06 00:00 [pmc-release]
AID - RNN170758 [pii]
AID - 10.3233/RNN-170758 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2017;35(5):547-556. doi: 10.3233/RNN-170758.