PMID- 28984774
OWN - NLM
STAT- MEDLINE
DCOM- 20171012
LR  - 20220419
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 40
DP  - 2017 Oct
TI  - A case report of tongue metastasis from lung squamous cell carcinoma and 
      literature review.
PG  - e8208
LID - 10.1097/MD.0000000000008208 [doi]
LID - e8208
AB  - RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the 
      prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man 
      was found a 4-cm cavity lesion in the left upper lobe, which was initially 
      misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell carcinoma 
      that metastasized to the base of a patient's tongue. INTERVATIONS: We send the 
      biopsy of the lung and the tongue lesions for gene sequencing. OUTCOMES: He 
      received systemic chemotherapy, but continued to have pain at the base of his 
      tongue and died 7 months later. LESSONS: From sequencing data, mutations in KRAS 
      proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase 
      catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the 
      tumor biopsy of the patient. All of these were indicators of poor prognosis.
FAU - Cheng, Xiaolong
AU  - Cheng X
AD  - Department of General Practice Department of Respiratory Medicine, Changhai 
      Hospital, The Second Military Medical University, Shanghai, China.
FAU - Hu, Zhenli
AU  - Hu Z
FAU - Han, Yi-Ping
AU  - Han YP
FAU - Bai, Chong
AU  - Bai C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
EIN - Medicine (Baltimore). 2017 Nov;96(47):e8909. PMID: 29382026
MH  - Carcinoma, Squamous Cell/genetics/*secondary
MH  - Fatal Outcome
MH  - Humans
MH  - Lung Neoplasms/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Mas
MH  - Tongue Neoplasms/genetics/*secondary
PMC - PMC5738010
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/10/07 06:00
MHDA- 2017/10/13 06:00
PMCR- 2017/10/27
CRDT- 2017/10/07 06:00
PHST- 2017/10/07 06:00 [entrez]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2017/10/13 06:00 [medline]
PHST- 2017/10/27 00:00 [pmc-release]
AID - 00005792-201710060-00025 [pii]
AID - MD-D-17-02110 [pii]
AID - 10.1097/MD.0000000000008208 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Oct;96(40):e8208. doi: 10.1097/MD.0000000000008208.