PMID- 2898523
OWN - NLM
STAT- MEDLINE
DCOM- 19880729
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 245
IP  - 3
DP  - 1988 Jun
TI  - Elevation of serum prolactin and corticosterone concentrations in the rat after 
      the administration of 3,4-methylenedioxymethamphetamine.
PG  - 873-9
AB  - The racemic mixture of 3,4-methylenedioxymethamphetamine (MDMA), which has been 
      reported to produce selective destruction of serotonergic neurons in the central 
      nervous system, was studied to determine its neuroendocrine and temperature 
      effects and mechanism of action. MDMA elevated serum concentrations of 
      corticosterone in doses ranging from 3 to 20 mg/kg administered i.p. Serum 
      corticosterone concentrations were elevated 30 min after the administration of 
      MDMA (10 mg/kg i.p.) and remained elevated 4 hr later. Serum prolactin (PRL) 
      concentrations were elevated by administration of MDMA in doses ranging from 1 to 
      20 mg/kg i.p., and were maximal 60 min after the injection of 10 mg/kg i.p., 
      declining rapidly over the next 4 hr. MDMA also significantly elevated the body 
      temperature of rats maintained at ambient (23 degrees C) temperature. 
      MDMA-induced corticosterone secretion and hyperthermia were blocked by the 
      5-hydroxytryptamine (5-HT) antagonists, ketanserin and mianserin, which have a 
      high affinity for 5-HT2 binding sites. Conversely, neither (-)-pindolol, a beta 
      antagonist that also blocks 5-HT1A-mediated responses, nor the nonspecific 5-HT 
      antagonists, cyproheptadine and metergoline, had an effect on MDMA-induced 
      corticosterone secretion. None of the 5-HT antagonists blocked MDMA-induced PRL 
      secretion. Pretreatment with fluoxetine (10 mg/kg i.p.) 16 hr before MDMA 
      administration significantly blunted the effect of MDMA on corticosterone but not 
      PRL secretion. Pretreatment with p-chlorophenylalanine (150 mg/kg i.p.) for 3 
      days depleted cortical and hypothalamic 5-HT and 5-hydroxyindoleacetic acid by 
      approximately 80% and significantly attenuated MDMA-induced corticosterone and 
      PRL secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Nash, J F Jr
AU  - Nash JF Jr
AD  - Department of Psychiatry, School of Medicine, Case Western Reserve University, 
      Cleveland, Ohio.
FAU - Meltzer, H Y
AU  - Meltzer HY
FAU - Gudelsky, G A
AU  - Gudelsky GA
LA  - eng
GR  - MH 41594/MH/NIMH NIH HHS/United States
GR  - MH 41683/MH/NIMH NIH HHS/United States
GR  - MH 41684/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Amphetamines)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Antagonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 9002-62-4 (Prolactin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R5J7E3L9SP (Fenclonine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Corticosterone/*blood
MH  - Dose-Response Relationship, Drug
MH  - Fenclonine/pharmacology
MH  - Fluoxetine/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Prolactin/*blood
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/drug effects
MH  - Serotonin Antagonists/pharmacology
EDAT- 1988/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1988 Jun;245(3):873-9.