PMID- 28985238
OWN - NLM
STAT- MEDLINE
DCOM- 20171019
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 10
DP  - 2017
TI  - The pain threshold of high-threshold mechanosensitive receptors subsequent to 
      maximal eccentric exercise is a potential marker in the prediction of DOMS 
      associated impairment.
PG  - e0185463
LID - 10.1371/journal.pone.0185463 [doi]
LID - e0185463
AB  - BACKGROUND: Delayed-onset muscle soreness (DOMS) refers to dull pain and 
      discomfort in people after participating in exercise, sport or recreational 
      physical activities. The aim of this study was to detect underlying mechanical 
      thresholds in an experimental model of DOMS. METHODS: Randomised study to detect 
      mechanical pain thresholds in a randomised order following experimentally induced 
      DOMS of the non-dominant arm in healthy participants. Main outcome was the 
      detection of the pressure pain threshold (PPT), secondary thresholds included 
      mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain 
      perceptions and the maximum isometric voluntary force (MIVF). RESULTS: Twenty 
      volunteers (9 female and 11 male, age 25.2 +/- 3.2 years, weight 70.5 +/- 10.8 kg, 
      height 177.4 +/- 9.4 cm) participated in the study. DOMS reduced the PPT (at 
      baseline 5.9 +/- 0.4 kg/cm2) by a maximum of 1.5 +/- 1.4 kg/cm2 (-24%) at 48 hours (p 
      < 0.001). This correlated with the decrease in MIVF (r = -0.48, p = 0.033). 
      Whereas subjective pain was an indicator of the early 48 hours, the PPT was still 
      present after 72 hours (r = 0.48, p = 0.036). Other mechanical thresholds altered 
      significantly due to DOMS, but did show no clinically or physiologically 
      remarkable changes. CONCLUSIONS: Functional impairment following DOMS seems 
      related to the increased excitability of high-threshold mechanosensitive 
      nociceptors. The PPT was the most valid mechanical threshold to quantify the 
      extent of dysfunction. Thus PPT rather than pain intensity should be considered a 
      possible marker indicating the athletes' potential risk of injury.
FAU - Fleckenstein, Johannes
AU  - Fleckenstein J
AUID- ORCID: 0000-0003-3442-0380
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe-University 
      Frankfurt, Frankfurt am Main, Germany.
FAU - Simon, Perikles
AU  - Simon P
AD  - Department of Sports Medicine, Johannes Gutenberg-University Mainz, Mainz, 
      Germany.
FAU - Konig, Matthias
AU  - Konig M
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe-University 
      Frankfurt, Frankfurt am Main, Germany.
AD  - Sport and Exercise Science Research Centre, School of Applied Sciences, London 
      South Bank University, London, United Kingdom.
AD  - Institute of Movement and Sport Gerontology, German Sport University Cologne, Am 
      Sportpark Mungersdorf 6, Cologne, Germany.
FAU - Vogt, Lutz
AU  - Vogt L
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe-University 
      Frankfurt, Frankfurt am Main, Germany.
FAU - Banzer, Winfried
AU  - Banzer W
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe-University 
      Frankfurt, Frankfurt am Main, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171006
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mechanoreceptors/*physiology
MH  - Muscle Contraction/physiology
MH  - Muscle, Skeletal/*physiology
MH  - Myalgia/*physiopathology
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - Pressure
MH  - Young Adult
PMC - PMC5630131
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/10/07 06:00
MHDA- 2017/10/20 06:00
PMCR- 2017/10/06
CRDT- 2017/10/07 06:00
PHST- 2016/05/03 00:00 [received]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/10/07 06:00 [entrez]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2017/10/20 06:00 [medline]
PHST- 2017/10/06 00:00 [pmc-release]
AID - PONE-D-16-17852 [pii]
AID - 10.1371/journal.pone.0185463 [doi]
PST - epublish
SO  - PLoS One. 2017 Oct 6;12(10):e0185463. doi: 10.1371/journal.pone.0185463. 
      eCollection 2017.