PMID- 28985587
OWN - NLM
STAT- MEDLINE
DCOM- 20180504
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 226
DP  - 2018 Jan 15
TI  - Cerebrospinal fluid D-serine concentrations in major depressive disorder 
      negatively correlate with depression severity.
PG  - 155-162
LID - S0165-0327(17)30775-9 [pii]
LID - 10.1016/j.jad.2017.09.035 [doi]
AB  - BACKGROUND: D-serine is an endogenous co-agonist of N-methyl-D-aspartate receptor 
      (NMDAR) and plays an important role in glutamate neurotransmission. Several 
      studies suggested the possible involvement of D-serine related in the 
      pathophysiology of psychiatric disorders including major depression disorders 
      (MDD). We tried to examine whether cerebrospinal fluid (CSF) or plasma D-serine 
      concentrations are altered in MDD and whether D-serine concentrations correlated 
      with disease severity. METHODS: 26 MDD patients and 27 healthy controls matched 
      for age, sex and ethnicity were enrolled. We measured amino acids in these 
      samples using by high-performance liquid chromatography with fluorometric 
      detection. RESULTS: D-serine and L-serine, precursor of D-serine, levels in CSF 
      or plasma were not significantly different in patients of MDD compared to 
      controls. Furthermore, a significant correlation between D-serine levels in CSF 
      and Hamilton Depression Rating Scale (HAMD)-17 score was observed (r = -0.65, p = 
      0.006). Furthermore, we found a positive correlation between CSF D-serine and HVA 
      concentrations in MDD patients (r = 0.54, p = 0.007). CSF D-serine concentrations 
      were correlated with those of plasma in MDD (r = 0.61, p = 0.01) but not in 
      controls. In CSF, we also confirmed a significant correlation between D-serine 
      and L-serine levels in MDD (r = 0.72, p < 0.0001) and controls (r = 0.70, p < 
      0.0001). CONCLUSIONS: The study has some limitations; sample size was relatively 
      small and most patients were medicated. We revealed that CSF D-serine 
      concentrations were correlated with depression severity and HVA concentrations 
      and further investigation were required to reveal the effect of medication and 
      disease heterogeneity.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ishiwata, Sayuri
AU  - Ishiwata S
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan; Department of 
      Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental 
      Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
FAU - Hattori, Kotaro
AU  - Hattori K
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan; Translational 
      Medical Center, National Center of Neurology and Psychiatry, Tokyo 187-8551, 
      Japan.
FAU - Sasayama, Daimei
AU  - Sasayama D
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Teraishi, Toshiya
AU  - Teraishi T
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan.
FAU - Miyakawa, Tomoko
AU  - Miyakawa T
AD  - Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo 
      187-8551, Japan.
FAU - Yokota, Yuuki
AU  - Yokota Y
AD  - Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo 
      187-8551, Japan.
FAU - Matsumura, Ryo
AU  - Matsumura R
AD  - Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo 
      187-8551, Japan.
FAU - Nishikawa, Toru
AU  - Nishikawa T
AD  - Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and 
      Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
FAU - Kunugi, Hiroshi
AU  - Kunugi H
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan. Electronic 
      address: hkunugi@ncnp.go.jp.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Adult
MH  - Chromatography, High Pressure Liquid
MH  - Depression/physiopathology
MH  - Depressive Disorder, Major/*cerebrospinal fluid/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Serine/*cerebrospinal fluid
MH  - Young Adult
OTO - NOTNLM
OT  - D-serine
OT  - Depression
OT  - HVA
OT  - L-serine
EDAT- 2017/10/07 06:00
MHDA- 2018/05/05 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/04/15 00:00 [received]
PHST- 2017/07/09 00:00 [revised]
PHST- 2017/09/23 00:00 [accepted]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/05/05 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
AID - S0165-0327(17)30775-9 [pii]
AID - 10.1016/j.jad.2017.09.035 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Jan 15;226:155-162. doi: 10.1016/j.jad.2017.09.035. Epub 
      2017 Sep 27.