PMID- 28985607
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181202
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 160
DP  - 2017 Dec 1
TI  - Design of pH/reduction dual-responsive nanoparticles as drug delivery system for 
      DOX: Modulating controlled release behavior with bimodal drug-loading.
PG  - 455-461
LID - S0927-7765(17)30627-6 [pii]
LID - 10.1016/j.colsurfb.2017.09.049 [doi]
AB  - pH/Reduction dual-responsive P(FPA-co-PEGMA-co-MAA) (PFPM) nanoparticles were 
      designed for tumor-specific intracellular triggered release of anticancer drug 
      DOX by emulsion copolymerization of 4-formylphenyl acrylate (FPA), methacrylic 
      acid (MAA), and poly(ethylene glycol) methyl ether methacrylate (PEGMA), with 
      N,N-bis(acryloyl)cystamine (BACy) as crosslinker. Then three drug delivery 
      systems (DDSs) with average hydrodynamic diameter around 200nm and drug-loading 
      capacity (DLC) of >35% were obtained via the noncovalent interaction of DOX with 
      the carboxyl and aldehyde groups in MAA and FPA units, covalently conjugating DOX 
      onto the FPA units via acid-labile imine bond, or both the two modes. The in 
      vitro release profiles showed that all the three DDSs exhibited good tumor 
      intracellular triggered release characteristic whitout burst release. And the 
      bimodal drug-loaded one (DOX/PFPM(C+N)), which had the highest DLC of >54%, 
      possessed the middle drug release rate, faster than the one via covalent 
      conjugation (DOX/PFPM(C)) but slower than the one via noncovalent interaction 
      (DOX/PFPM(N)). The results demonstrated that the controlled release behavior of 
      such functional nanoparticles could be tailored with drug-loading modes.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry and Key Laboratory of 
      Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College 
      of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. 
      Electronic address: pliu@lzu.edu.cn.
FAU - Zhang, Ruinian
AU  - Zhang R
AD  - State Key Laboratory of Applied Organic Chemistry and Key Laboratory of 
      Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College 
      of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Pei, Mingliang
AU  - Pei M
AD  - State Key Laboratory of Applied Organic Chemistry and Key Laboratory of 
      Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College 
      of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
LA  - eng
PT  - Journal Article
DEP - 20170922
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Acrylates)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Emulsions)
RN  - 0 (Methacrylates)
RN  - 0 (polyethylene glycol methacrylate)
RN  - 1CS02G8656 (methacrylic acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Acrylates/chemistry
MH  - Antibiotics, Antineoplastic/administration & dosage/chemistry/pharmacokinetics
MH  - Delayed-Action Preparations/*administration & dosage/chemistry/pharmacokinetics
MH  - Doxorubicin/*administration & dosage/chemistry/pharmacokinetics
MH  - Drug Compounding
MH  - Drug Delivery Systems/*methods
MH  - Drug Liberation
MH  - Emulsions/chemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Methacrylates/chemistry
MH  - Microscopy, Electron, Transmission
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Polyethylene Glycols/chemistry
MH  - Polymerization
OTO - NOTNLM
OT  - Anti-cancer drug
OT  - Bimodal drug-loading
OT  - Intracellular triggered release
OT  - Modulating controlled release
OT  - Polymer nanoparticles
EDAT- 2017/10/07 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/10/07 06:00
PHST- 2017/06/24 00:00 [received]
PHST- 2017/09/14 00:00 [revised]
PHST- 2017/09/21 00:00 [accepted]
PHST- 2017/10/07 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/10/07 06:00 [entrez]
AID - S0927-7765(17)30627-6 [pii]
AID - 10.1016/j.colsurfb.2017.09.049 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2017 Dec 1;160:455-461. doi: 
      10.1016/j.colsurfb.2017.09.049. Epub 2017 Sep 22.