PMID- 28986198
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20220321
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 26
IP  - 12
DP  - 2017 Dec
TI  - Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of 
      Atherosclerosis.
PG  - 2695-2699
LID - S1052-3057(16)30400-1 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2016.10.012 [doi]
AB  - BACKGROUND: The mechanisms of hyperhomocysteinemia (HHcy) and hyperuricemia (HUA) 
      that promote atherosclerosis were seldom explored and always indefinite. 
      Therefore, we will discuss some new reviews about the role of HHcy and HUA in the 
      pathogenesis of atherosclerosis. METHODS: This study was conducted by reading a 
      lot of literature, including basic research and clinical application research. 
      RESULTS: HHcy is known as an independent risk factor for atherosclerosis. 
      Possible mechanisms for the association between homocysteine and atherosclerosis 
      include stimulating smooth muscle cell growth, reducing endothelial cell growth 
      and endothelial cell relaxation, and decreasing synthesis of high-density 
      lipoprotein. HUA causes endothelial dysfunction and thereby increases oxidative 
      stress, inducing vascular smooth muscle cell proliferation and reducing 
      endothelial nitric oxide bioavailability. HUA plays a role in the development and 
      pathogenesis of metabolic syndrome, hypertension, stroke, and atherosclerosis. 
      CONCLUSIONS: Accelerated atherosclerosis may be a consequence of the combined 
      effect of HHcy and HUA.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Zhao, Junjie
AU  - Zhao J
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
FAU - Chen, Hailin
AU  - Chen H
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
FAU - Liu, Ning
AU  - Liu N
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China. 
      Electronic address: Lnning1957@sina.com.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
FAU - Gu, Youquan
AU  - Gu Y
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
FAU - Chen, Jiangjun
AU  - Chen J
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
FAU - Yang, Kui
AU  - Yang K
AD  - Department of Neurology, Zhoukou Central Hospital, Zhoukou, Henan 466000, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171003
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 268B43MJ25 (Uric Acid)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/blood/*etiology/pathology/physiopathology
MH  - Biomarkers/blood
MH  - Cell Proliferation
MH  - Endoplasmic Reticulum Stress
MH  - Endothelium, Vascular/metabolism/pathology/physiopathology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications
MH  - Hyperuricemia/blood/*complications
MH  - Inflammation/blood/etiology
MH  - Inflammation Mediators/metabolism
MH  - Muscle, Smooth, Vascular/metabolism/pathology/physiopathology
MH  - Nitric Oxide/metabolism
MH  - Oxidative Stress
MH  - Risk Factors
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - Hyperhomocysteinemia
OT  - atherosclerosis
OT  - hyperuricemia
OT  - mechanisms
EDAT- 2017/10/08 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/10/08 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2016/10/01 00:00 [revised]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2017/10/08 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/10/08 06:00 [entrez]
AID - S1052-3057(16)30400-1 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2016.10.012 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2017 Dec;26(12):2695-2699. doi: 
      10.1016/j.jstrokecerebrovasdis.2016.10.012. Epub 2017 Oct 3.