PMID- 28986537
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Oct 6
TI  - Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin 
      expression in endothelial cells.
PG  - 12762
LID - 10.1038/s41598-017-13008-9 [doi]
LID - 12762
AB  - Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- and 
      disease-associated matrix components with pro- and anti-adhesive activity, 
      respectively. Whereas both are present in the tumour vasculature, their 
      functional interplay on vascular endothelial cells remains unclear. We have 
      previously shown that basally-oriented deposition of a FN matrix restricts 
      motility and promotes junctional stability in cultured endothelial cells and that 
      this effect is tightly coupled to expression of FN. Here we report that TNC 
      induces FN expression in endothelial cells. This effect counteracts the potent 
      anti-adhesive activity of TNC and leads to the assembly of a dense 
      highly-branched subendothelial matrix that enhances tubulogenic activity. These 
      findings suggest that pro-angiogenic remodelling of the perivascular matrix may 
      involve TNC-induced upregulation of FN in endothelial cells.
FAU - Radwanska, Agata
AU  - Radwanska A
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
FAU - Grall, Dominique
AU  - Grall D
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
FAU - Schaub, Sebastien
AU  - Schaub S
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
FAU - Divonne, Stephanie Beghelli-de la Forest
AU  - Divonne SBF
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
AD  - Centre Antoine Lacassagne, Nice, 06189, France.
FAU - Ciais, Delphine
AU  - Ciais D
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
FAU - Rekima, Samah
AU  - Rekima S
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
FAU - Rupp, Tristan
AU  - Rupp T
AD  - Inserm, U1109, MN3T laboratory, The Microenvironmental Niche in Tumorigenesis and 
      Targeted Therapy, Strasbourg, F-67000, France.
AD  - University Strasbourg, Strasbourg, F-67000, France.
FAU - Sudaka, Anne
AU  - Sudaka A
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France.
AD  - Centre Antoine Lacassagne, Nice, 06189, France.
FAU - Orend, Gertraud
AU  - Orend G
AD  - Inserm, U1109, MN3T laboratory, The Microenvironmental Niche in Tumorigenesis and 
      Targeted Therapy, Strasbourg, F-67000, France.
AD  - University Strasbourg, Strasbourg, F-67000, France.
FAU - Van Obberghen-Schilling, Ellen
AU  - Van Obberghen-Schilling E
AUID- ORCID: 0000-0003-2961-0059
AD  - Universite Cote d'Azur, CNRS, INSERM, iBV, France. vanobber@unice.fr.
AD  - Centre Antoine Lacassagne, Nice, 06189, France. vanobber@unice.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171006
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Fibronectins)
RN  - 0 (Tenascin)
SB  - IM
MH  - Capillaries/metabolism
MH  - Cell Adhesion
MH  - Cell Movement
MH  - Cell-Matrix Junctions
MH  - Fibronectins/*metabolism
MH  - Human Umbilical Vein Endothelial Cells/*cytology/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Neoplasms/blood supply/metabolism/pathology
MH  - Neovascularization, Pathologic/metabolism
MH  - Neovascularization, Physiologic
MH  - Signal Transduction
MH  - Tenascin/*metabolism
PMC - PMC5630602
COIS- The authors declare that they have no competing interests.
EDAT- 2017/10/08 06:00
MHDA- 2019/06/30 06:00
PMCR- 2017/10/06
CRDT- 2017/10/08 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2017/10/08 06:00 [entrez]
PHST- 2017/10/08 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2017/10/06 00:00 [pmc-release]
AID - 10.1038/s41598-017-13008-9 [pii]
AID - 13008 [pii]
AID - 10.1038/s41598-017-13008-9 [doi]
PST - epublish
SO  - Sci Rep. 2017 Oct 6;7(1):12762. doi: 10.1038/s41598-017-13008-9.