PMID- 28986597
OWN - NLM
STAT- MEDLINE
DCOM- 20171018
LR  - 20180316
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 12
DP  - 2017 Oct 1
TI  - Associations Between Outer Retinal Structures and Focal Macular 
      Electroretinograms in Patients With Retinitis Pigmentosa.
PG  - 5122-5128
LID - 10.1167/iovs.17-22040 [doi]
AB  - PURPOSE: Our earlier study showed that the width of the intact ellipsoid zone 
      (EZ) of the photoreceptors was significantly but weakly correlated with the 
      amplitudes of the focal macular ERGs (FMERGs). The aim of this study was to 
      determine a microstructure of the photoreceptors in the spectral-domain optical 
      coherence tomographic (SD-OCT) images that was more strongly correlated with the 
      FMERG parameters in eyes with retinitis pigmentosa (RP). METHODS: This was a 
      retrospective, observational study. The medical records of 65 patients with RP 
      were reviewed. FMERGs were elicited by a 15-degree stimulus spot. The width of 
      the EZ and the outer segment (OS) area surrounded by EZ and retinal pigment 
      epithelium in the SD-OCT images within 15 degrees of the fovea were evaluated. 
      Spearman correlation tests and multiple stepwise regression analyses were 
      performed. RESULTS: There was a strong correlation between the amplitudes of 
      FMERGs and the EZ width (r = 0.68 for a-wave amplitude; r = 0.64 for b-wave 
      amplitude), and also between the amplitudes of the FMERGs and the OS area (r = 
      0.69 for a-wave amplitude; r = 0.67 for b-wave amplitude). However, some patients 
      had long EZ widths but had severely reduced FMERGs. Multiple stepwise regression 
      analyses showed that the OS area was the only significant independent predictor 
      of the amplitudes of FMERGs (P < 0.001). CONCLUSIONS: The OS area might be a 
      better morphological structure to use to predict the physiological function of 
      the macula.
FAU - Kominami, Taro
AU  - Kominami T
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Ueno, Shinji
AU  - Ueno S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kominami, Azusa
AU  - Kominami A
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Nakanishi, Ayami
AU  - Nakanishi A
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Yasuda, Shunsuke
AU  - Yasuda S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Piao, Chang-Hua
AU  - Piao CH
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Okado, Satoshi
AU  - Okado S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Terasaki, Hiroko
AU  - Terasaki H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - *Electroretinography
MH  - Female
MH  - Humans
MH  - Macula Lutea/*physiology
MH  - Male
MH  - Middle Aged
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Ganglion Cells/physiology
MH  - Retinitis Pigmentosa/*physiopathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence/methods
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2017/10/08 06:00
MHDA- 2017/10/19 06:00
CRDT- 2017/10/08 06:00
PHST- 2017/10/08 06:00 [entrez]
PHST- 2017/10/08 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
AID - 2657408 [pii]
AID - 10.1167/iovs.17-22040 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5122-5128. doi: 
      10.1167/iovs.17-22040.