PMID- 28987361
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20220809
IS  - 2224-6614 (Electronic)
IS  - 1021-9498 (Print)
VI  - 25
IP  - 4
DP  - 2017 Oct
TI  - Comparative effect of horse gram and black gram on inflammatory mediators and 
      antioxidant status.
PG  - 845-853
LID - 10.1016/j.jfda.2016.08.010 [doi]
AB  - A balanced diet is important for the overall wellbeing of an individual. Pulses 
      are an important part of a nutritive diet. Pulses have been consumed for at least 
      10,000 years and are among the most extensively used foods in the world. They are 
      a rich source of protein and fiber, as well as a significant source of vitamins 
      and minerals, such as iron, zinc, and magnesium. The purpose of this study was to 
      compare the effect of two pulses, horse gram and black gram, on inflammatory 
      mediators and the antioxidant enzymes. Two sets of experiments were conducted in 
      rats which were fed with boiled and unboiled horse gram and black gram, at a dose 
      of 100 mg/100 g body weight, for 21 days and 60 days. The results showed that 
      horse gram supplementation for 21 days and 60 days significantly increased the 
      activities of antioxidant enzymes such as superoxide dismutase, catalase, 
      glutathione peroxidase and showed no significant changes in the activities of the 
      inflammatory mediators such as cyclooxygenase, lipoxygenase, myeloperoxidase, 
      nitric oxide synthase, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-1-beta (IL-1beta), etc. However, the black gram 
      (with skin and without skin) supplementation significantly increased activities 
      of the inflammatory mediators and showed a significant decrease in the 
      antioxidant enzymes in both the 21-day and 60-day experiments. Thus, these 
      preliminary results demonstrate the anti-inflammatory and antioxidant potential 
      of horse gram and the proinflammatory effects of black gram in rats. This is in 
      accordance with the dietary regime advised by Ayurveda practitioners, where horse 
      gram is to be included and black gram is to be excluded from the diet for 
      conditions such as rheumatoid arthritis. Further studies are to be conducted to 
      validate the same.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Rajagopal, Vrinda
AU  - Rajagopal V
AD  - Department of Biochemistry, University of Kerala, Kariavattom Campus, 
      Thiruvananthpuram, Kerala, India.
FAU - Pushpan, Chithra K
AU  - Pushpan CK
AD  - Department of Biochemistry, University of Kerala, Kariavattom Campus, 
      Thiruvananthpuram, Kerala, India.
FAU - Antony, Helen
AU  - Antony H
AD  - Department of Biochemistry, University of Kerala, Kariavattom Campus, 
      Thiruvananthpuram, Kerala, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20161111
PL  - China (Republic : 1949- )
TA  - J Food Drug Anal
JT  - Journal of food and drug analysis
JID - 101630927
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-1)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Antioxidants/*metabolism
MH  - Catalase/genetics/metabolism
MH  - Fabaceae/*chemistry/metabolism
MH  - Female
MH  - Glutathione Peroxidase/genetics/metabolism
MH  - Inflammation Mediators/*immunology
MH  - Interleukin-1/genetics/immunology
MH  - Monocytes/drug effects/immunology
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
MH  - Vigna/*chemistry/metabolism
PMC - PMC9328873
OTO - NOTNLM
OT  - antioxidant
OT  - black gram
OT  - horse gram
OT  - inflammation
COIS- Conflicts of interest All contributing authors declare no conflicts of interest.
EDAT- 2017/10/11 06:00
MHDA- 2018/02/16 06:00
PMCR- 2016/11/11
CRDT- 2017/10/09 06:00
PHST- 2016/03/03 00:00 [received]
PHST- 2016/07/27 00:00 [revised]
PHST- 2016/08/31 00:00 [accepted]
PHST- 2017/10/09 06:00 [entrez]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2016/11/11 00:00 [pmc-release]
AID - j.jfda.2016.08.010 [pii]
AID - jfda-25-04-845 [pii]
AID - 10.1016/j.jfda.2016.08.010 [doi]
PST - ppublish
SO  - J Food Drug Anal. 2017 Oct;25(4):845-853. doi: 10.1016/j.jfda.2016.08.010. Epub 
      2016 Nov 11.