PMID- 28987363
OWN - NLM
STAT- MEDLINE
DCOM- 20180215
LR  - 20220809
IS  - 2224-6614 (Electronic)
IS  - 1021-9498 (Print)
VI  - 25
IP  - 4
DP  - 2017 Oct
TI  - Extract from Mulberry (Morus australis) leaf decelerate acetaminophen induced 
      hepatic inflammation involving downregulation of myeloid differentiation factor 
      88 (MyD88) signals.
PG  - 862-871
LID - 10.1016/j.jfda.2016.07.011 [doi]
AB  - Acetaminophen (APAP) induced inflammation and oxidative stress can cause cell 
      death to induce liver damage. The antioxidative and anti-inflammatory effect of 
      Mulberry (Morus australis) leaf extract (MLE) was shown in previous studies. In 
      this study, we investigated the modulation of MLE on APAP induced inflammation 
      and oxidative stress in rat liver injury or liver cancer cell (HepG2). Wistar rat 
      was fed orally with MLE (0.5% or 1.0 %) for 1 week, and then, 900 mg/kg of APAP 
      was injected intraperitoneally (i.p.). Pretreatment of MLE decreased obvious foci 
      of inflammatory cell infiltration in liver. It also reduced the expression of 
      inflammatory parameters including cyclooxygenase-2 (COX-2), inducible nitric 
      oxide synthase (iNOS), and nuclear factor kappa B (NF-kappaB) in liver. Treating with 
      MLE increased the antioxidative enzymes such as superoxide dismutase (SOD), 
      glutathione peroxidase (GSH-Px), and catalase. Giving APAP to HepG2 hepatocyte 
      was conducted to elucidate the mechanism of MLE or its functional components. The 
      result showed that APAP upregulated hepatic protein expression of (myeloid 
      differentiation factor 88) MyD88, nuclear factor kappa B (NF-kB), inhibitor of 
      kappa B (IkB), c-Jun N-terminal kinases (JNK), and receptor interacting proteins 
      (RIP1 and RIP3). Pretreatment of MLE, gallic acid (GA), gallocatechin gallate 
      (GCG), or protocatechuic acid (PCA) suppressed the indicated protein expression. 
      These findings confirmed that MLE has the potential to protect liver from 
      APAP-induced inflammation, and the protecting mechanism might involve decreasing 
      oxidative stress and regulating the innate immunity involving MyD88.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Horng, Chi-Ting
AU  - Horng CT
AD  - Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung 
      Shan Medical University, Taichung, Taiwan.
AD  - Medical Education Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 
      City, Taiwan.
FAU - Liu, Zhi-Hong
AU  - Liu ZH
AD  - Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung 
      Shan Medical University, Taichung, Taiwan.
FAU - Huang, Yu-Ting
AU  - Huang YT
AD  - Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung 
      Shan Medical University, Taichung, Taiwan.
FAU - Lee, Huei-Jane
AU  - Lee HJ
AD  - Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung 
      Shan Medical University, Taichung, Taiwan.
AD  - Department of Biochemistry, School of Medicine, Medical College, Chung Shan 
      Medical University, Taichung, Taiwan.
AD  - Department of Clinical Biochemistry, Chung Shan Medical University Hospital, 
      Taichung, Taiwan.
FAU - Wang, Chau-Jong
AU  - Wang CJ
AD  - Institute of Biochemistry, Microbiology and Immunology, Medical College, Chung 
      Shan Medical University, Taichung, Taiwan.
AD  - Department of Clinical Biochemistry, Chung Shan Medical University Hospital, 
      Taichung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20161105
PL  - China (Republic : 1949- )
TA  - J Food Drug Anal
JT  - Journal of food and drug analysis
JID - 101630927
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Plant Extracts)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*adverse effects
MH  - Animals
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/etiology/genetics/immunology
MH  - Down-Regulation
MH  - Humans
MH  - Liver/drug effects/immunology
MH  - Male
MH  - Morus/*chemistry
MH  - Myeloid Differentiation Factor 88/*genetics/immunology
MH  - Oxidative Stress
MH  - Plant Extracts/*administration & dosage/isolation & purification
MH  - Plant Leaves/*chemistry
MH  - Rats, Wistar
PMC - PMC9328886
OTO - NOTNLM
OT  - acetaminophen
OT  - antiinflammation
OT  - antioxidation
OT  - mulberry leaf
COIS- Conflicts of interest The authors declare no competing financial interest.
EDAT- 2017/10/11 06:00
MHDA- 2018/02/16 06:00
PMCR- 2016/11/05
CRDT- 2017/10/09 06:00
PHST- 2016/06/13 00:00 [received]
PHST- 2016/07/26 00:00 [revised]
PHST- 2016/07/27 00:00 [accepted]
PHST- 2017/10/09 06:00 [entrez]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/02/16 06:00 [medline]
PHST- 2016/11/05 00:00 [pmc-release]
AID - j.jfda.2016.07.011 [pii]
AID - jfda-25-04-862 [pii]
AID - 10.1016/j.jfda.2016.07.011 [doi]
PST - ppublish
SO  - J Food Drug Anal. 2017 Oct;25(4):862-871. doi: 10.1016/j.jfda.2016.07.011. Epub 
      2016 Nov 5.