PMID- 28987501
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20181202
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 107
IP  - 2
DP  - 2018 Feb
TI  - Composite Alginate-Hyaluronan Sponges for the Delivery of Tranexamic Acid in 
      Postextractive Alveolar Wounds.
PG  - 654-661
LID - S0022-3549(17)30684-6 [pii]
LID - 10.1016/j.xphs.2017.09.026 [doi]
AB  - The management of wounds in patients on anticoagulant therapy who require oral 
      surgical procedures is problematic and often results in a nonsatisfactory healing 
      process. Here, we report a method to prepare an advanced dressing able to avoid 
      uncontrolled bleeding by occluding the postextractive alveolar wounds, and 
      simultaneously, capable of a fast release of tranexamic acid (TA). Composite 
      alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a 
      straightforward internal gelation method followed by a freeze-drying step. Both 
      blank and drug-loaded sponges were soft, flexible, and elegant in appearance and 
      nonbrittle in nature. Scanning electron microscopy analysis confirmed the porous 
      nature of these dressings. The integration of HA influenced the microstructure, 
      reducing the porosity, modifying the water uptake kinetic, and increasing the 
      resistance to compression. TA release from ALG/HA sponges showed a controlled 
      release up to 3 h, and it was faster in the presence of HA. Finally, an in vitro 
      clotting test performed on human whole blood confirmed that the TA-loaded sponges 
      significantly reduce the blood clotting index by 30% compared with ALG/HA(20) 
      sponges. These results suggest that, if placed in a socket cavity, these 
      dressings could give a relevant help to the blood hemostasis after dental 
      extractions, especially in patients with coagulation disorders.
CI  - Copyright (c) 2018 American Pharmacists Association(R). Published by Elsevier Inc. 
      All rights reserved.
FAU - Catanzano, Ovidio
AU  - Catanzano O
AD  - Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 
      Naples 80131, Italy; Department of Pharmaceutical, Chemical and Environmental 
      Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, 
      Central Avenue, Chatham Maritime, Kent ME4 4TB, UK. Electronic address: 
      ovid@hotmail.it.
FAU - D'Esposito, Vittoria
AU  - D'Esposito V
AD  - Department of Translational Medical Sciences, University of Naples Federico II, 
      Via S. Pansini 5, Naples 80131, Italy.
FAU - Formisano, Pietro
AU  - Formisano P
AD  - Department of Translational Medical Sciences, University of Naples Federico II, 
      Via S. Pansini 5, Naples 80131, Italy.
FAU - Boateng, Joshua S
AU  - Boateng JS
AD  - Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of 
      Engineering and Science, University of Greenwich, Medway, Central Avenue, Chatham 
      Maritime, Kent ME4 4TB, UK.
FAU - Quaglia, Fabiana
AU  - Quaglia F
AD  - Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 
      Naples 80131, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171005
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Alginates)
RN  - 0 (Hexuronic Acids)
RN  - 6T84R30KC1 (Tranexamic Acid)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Alginates/*chemistry
MH  - Bandages
MH  - Freeze Drying/methods
MH  - Glucuronic Acid/chemistry
MH  - Hexuronic Acids/chemistry
MH  - Humans
MH  - Hyaluronic Acid/*chemistry
MH  - Porosity
MH  - Tranexamic Acid/*chemistry
MH  - Wound Healing/*drug effects
OTO - NOTNLM
OT  - alginate
OT  - biodegradable polymers
OT  - controlled delivery
OT  - mechanical properties
OT  - wound healing
EDAT- 2017/10/11 06:00
MHDA- 2018/09/12 06:00
CRDT- 2017/10/09 06:00
PHST- 2017/08/23 00:00 [received]
PHST- 2017/09/15 00:00 [revised]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2017/10/09 06:00 [entrez]
AID - S0022-3549(17)30684-6 [pii]
AID - 10.1016/j.xphs.2017.09.026 [doi]
PST - ppublish
SO  - J Pharm Sci. 2018 Feb;107(2):654-661. doi: 10.1016/j.xphs.2017.09.026. Epub 2017 
      Oct 5.