PMID- 28988596
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20180926
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 12
IP  - 3
DP  - 2018 May
TI  - TNF-alpha/IL-10 ratio: An independent predictor for coronary artery disease in North 
      Indian population.
PG  - 221-225
LID - S1871-4021(17)30290-4 [pii]
LID - 10.1016/j.dsx.2017.09.006 [doi]
AB  - BACKGROUND/AIM: Cytokines are responsible for the modulation of immunological and 
      inflammatory processes and play a significant role in the pathogenesis of 
      coronary artery disease (CAD). Tumor necrosis factor-alpha (TNF-alpha) are considered 
      as a pro inflammatory and interleukin-10 (IL-10) anti inflammatory have been 
      shown to predict the risk of incident of CAD. Aim of present study is to examine 
      the impact of the TNF-alpha and Il-10 levels on various components of the CAD. 
      METHODS: Total 580 subjects were recruited in the present study out of which 290 
      diagnosed CAD subjects (Age 51.61+/-9.26; BMI 25.27+/-3.58) and 290 healthy controls 
      (Age 51.72+/-9.48; BMI 24.02+/-7.42). Serum TNF-alpha and IL-10 levels were measured 
      by ELISA. RESULTS: Data of present study revealed that CAD patients had higher 
      frequency (p=0.001) of smoking (38.28%), Alcohol (21.03%), Diabetes (53.45%) and 
      hypertension (48.28%) as compare to controls. Moreover, we have observed highly 
      significant (p<0.05) difference in PR, BMI, DBP, DBP, Glucose, TC, TG, VLDL, LDL, 
      TNF-alpha and TNF-alpha/IL-10. However, HDL and IL-10 were found lower in CAD. 
      CONCLUSION: The findings of present study suggest that the TNF-alpha/IL-10 ratio may 
      play a vital role in the development of CAD of North Indian population.
CI  - Copyright (c) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Kumari, Reena
AU  - Kumari R
AD  - Department of Biochemistry, KGMU, Lucknow 226003, India; Department of Zoology, 
      University of Lucknow, Lucknow 226007, India. Electronic address: 
      Reena.xlnet@gmail.com.
FAU - Kumar, Sandeep
AU  - Kumar S
AD  - Department of Clinical Immunology, SGPGIMS, Lucknow 226014, India.
FAU - Ahmad, M Kaleem
AU  - Ahmad MK
AD  - Department of Biochemistry, KGMU, Lucknow 226003, India.
FAU - Singh, Rajeev
AU  - Singh R
AD  - Department of Biochemistry, KGMU, Lucknow 226003, India.
FAU - Pradhan, Akshayaya
AU  - Pradhan A
AD  - Department of Cardiology, KGMU, Lucknow 226003, India.
FAU - Chandra, Sharad
AU  - Chandra S
AD  - Department of Cardiology, KGMU, Lucknow 226003, India.
FAU - Kumar, Sudhir
AU  - Kumar S
AD  - Department of Zoology, University of Lucknow, Lucknow 226007, India.
LA  - eng
PT  - Journal Article
DEP - 20170922
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (IL10 protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*blood/diagnosis/epidemiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - India/epidemiology
MH  - Interleukin-10/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - BMI
OT  - Coronary artery disease
OT  - ELISA
OT  - IL-10
OT  - TNF-alpha
EDAT- 2017/10/11 06:00
MHDA- 2018/09/27 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/08/10 00:00 [received]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
AID - S1871-4021(17)30290-4 [pii]
AID - 10.1016/j.dsx.2017.09.006 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2018 May;12(3):221-225. doi: 10.1016/j.dsx.2017.09.006. 
      Epub 2017 Sep 22.