PMID- 28988708
OWN - NLM
STAT- MEDLINE
DCOM- 20190730
LR  - 20190730
IS  - 1878-0938 (Electronic)
IS  - 1878-0938 (Linking)
VI  - 19
IP  - 3 Pt B
DP  - 2018 Apr-May
TI  - Efficacy of a heparin based rota-flush solution in patients undergoing rotational 
      atherectomy.
PG  - 333-337
LID - S1553-8389(17)30331-7 [pii]
LID - 10.1016/j.carrev.2017.08.013 [doi]
AB  - INTRODUCTION: The efficacy of heparin based flush solutions in rotational 
      atherectomy (RA) has not been validated. Recently, a single center study 
      demonstrated the feasibility of an alternative flush solution with 10,000U of 
      unfractionated heparin (UFH) in 1L of normal saline. We aimed to evaluate the 
      safety and efficacy of an alternative flush solution intermittently utilized at 
      our institution. METHODS: We retrospectively identified 150 patients undergoing 
      RA over a three year period. One hundred cases utilized an alternative flush 
      solution containing 10,000U UFH, 400mcg nitroglycerin, and 10mg verapamil in 1L 
      normal saline and fifty cases utilized RotaGlide Lubricant (Boston Scientific) in 
      addition to heparin and vasodilators in the same dose. The primary end point was 
      to compare rates of procedural success. Secondary endpoints were to report 
      procedural characteristics including the incidence of major adverse cardiac 
      events (MACE) and minor periprocedural complications. RESULTS: Procedural success 
      was achieved in 98% (98/100) of cases utilizing the alternative Rota-Flush 
      solution compared to 100% (50/50) in the Rota-Glide group (P=0.553). A total of 
      292 lesions (200 Rota-Flush vs 92 Rota-Glide) were targeted for intervention. 
      MACE occurred in 13 (13%) and 4 (8%) cases in the Rota-Flush and Rota-Glide 
      groups, respectively (P=0.425). CONCLUSION: Rotational atherectomy performed with 
      the previously defined Rota-Flush or Rota-Glide solutions resulted in similar 
      rates of procedural success. There were no significant disparities in incidence 
      of MACE and minor periprocedural complications between the two groups. Heparin 
      based rota-flush solutions can be effective alternatives to traditional solutions 
      containing RotaGlide Lubricant.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Whiteside, Hoyle L
AU  - Whiteside HL
AD  - Department of Internal Medicine, Medical College of Georgia, Augusta University, 
      Augusta, GA, USA. Electronic address: hwhiteside@augusta.edu.
FAU - Ratanapo, Supawat
AU  - Ratanapo S
AD  - Department of Cardiology, Medical College of Georgia, Augusta University, 
      Augusta, GA, USA.
FAU - Sey, Albert
AU  - Sey A
AD  - Department of Cardiology, Medical College of Georgia, Augusta University, 
      Augusta, GA, USA.
FAU - Omar, Abdullah
AU  - Omar A
AD  - Department of Cardiology, Medical College of Georgia, Augusta University, 
      Augusta, GA, USA.
FAU - Kapoor, Deepak
AU  - Kapoor D
AD  - Department of Cardiology, Medical College of Georgia, Augusta University, 
      Augusta, GA, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170825
PL  - United States
TA  - Cardiovasc Revasc Med
JT  - Cardiovascular revascularization medicine : including molecular interventions
JID - 101238551
RN  - 0 (Anticoagulants)
RN  - 0 (Lubricants)
RN  - 9005-49-6 (Heparin)
MH  - Aged
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - *Atherectomy, Coronary/adverse effects
MH  - Coronary Artery Disease/diagnostic imaging/*surgery
MH  - Female
MH  - Heparin/*administration & dosage/adverse effects
MH  - Humans
MH  - Lubricants/*administration & dosage/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Vascular Calcification/diagnostic imaging/*surgery
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Percutaneous coronary intervention
OT  - Rotational atherectomy
EDAT- 2017/10/11 06:00
MHDA- 2019/07/31 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/07/09 00:00 [received]
PHST- 2017/08/18 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2019/07/31 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
AID - S1553-8389(17)30331-7 [pii]
AID - 10.1016/j.carrev.2017.08.013 [doi]
PST - ppublish
SO  - Cardiovasc Revasc Med. 2018 Apr-May;19(3 Pt B):333-337. doi: 
      10.1016/j.carrev.2017.08.013. Epub 2017 Aug 25.