PMID- 2898891
OWN - NLM
STAT- MEDLINE
DCOM- 19880805
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 1
DP  - 1988 Jul
TI  - Human T-cell lymphotropic virus I and adult T-cell leukemia: report of a cluster 
      in North Carolina.
PG  - 51-8
AB  - PURPOSE: Human adult T-cell leukemia-lymphoma is a malignant, proliferative 
      disease of CD4+ lymphocytes associated with infection with human T-cell 
      lymphotropic virus type I (HTLV-I). Following the presentation of a patient who 
      was infected with the virus, we undertook a study of his family members and 
      sexual contacts to see if a cluster of infected persons could be identified. CASE 
      REPORT: A black heterosexual North Carolina native with a history of drug abuse 
      presented with jaundice, and pancytopenia subsequently developed. He then became 
      hypercalcemic and leukemic, with high numbers of circulating, morphologically 
      abnormal CD4+ lymphocytes. RESULTS: As determined by radioimmunoassay and 
      immunoblot analyses, the serum of the index case contained antibodies against 
      core proteins (p19 and p24) of HTLV-I. When cultured in vitro with interleukin-2, 
      the lymphocytes expressed HTLV-I specific core proteins. The virus recovered from 
      these T cells was transmitted to cord blood T cells, which became immortalized 
      for continuous growth in vitro, expressed HTLV-I p19 protein, and displayed 
      characteristic C-type particles by electron microscopy. Studies of family members 
      and sexual contacts, all of whom were black, heterosexual central North Carolina 
      natives, revealed five of 28 whose serum had anti-HTLV-I antibodies as determined 
      by radioimmunoassay and immunoblot. Neither the patient nor the seropositive 
      family/contacts had antibodies against human immunodeficiency virus proteins. 
      Four of the six people with HTLV-I infection had no history of intravenous drug 
      abuse. Three of the five seropositive family/contacts had circulating, 
      morphologically abnormal lymphocytes suggestive of "preleukemic" or "smoldering" 
      human adult T-cell leukemia-lymphoma.
FAU - Weinberg, J B
AU  - Weinberg JB
AD  - Department of Medicine, Veterans Administration Medical Center, Durham, North 
      Carolina 27705.
FAU - Spiegel, R A
AU  - Spiegel RA
FAU - Blazey, D L
AU  - Blazey DL
FAU - Janssen, R S
AU  - Janssen RS
FAU - Kaplan, J E
AU  - Kaplan JE
FAU - Robert-Guroff, M
AU  - Robert-Guroff M
FAU - Popovic, M
AU  - Popovic M
FAU - Matthews, T J
AU  - Matthews TJ
FAU - Haynes, B F
AU  - Haynes BF
FAU - Palker, T J
AU  - Palker TJ
LA  - eng
GR  - AI-23308/AI/NIAID NIH HHS/United States
GR  - CA-28936/CA/NCI NIH HHS/United States
GR  - CA-40660/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/analysis
MH  - Deltaretrovirus/immunology
MH  - Deltaretrovirus Infections/*epidemiology/immunology/transmission
MH  - Humans
MH  - Male
MH  - North Carolina
MH  - Pedigree
MH  - Sexual Partners
MH  - Space-Time Clustering
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 0002-9343(88)90502-5 [pii]
AID - 10.1016/0002-9343(88)90502-5 [doi]
PST - ppublish
SO  - Am J Med. 1988 Jul;85(1):51-8. doi: 10.1016/0002-9343(88)90502-5.