PMID- 28988972
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180702
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 662
DP  - 2018 Jan 1
TI  - Arginine vasopressin antagonizes the effects of prostaglandin E(2) on the 
      spontaneous activity of warm-sensitive and temperature-insensitive neurons in the 
      medial preoptic area in rats.
PG  - 59-64
LID - S0304-3940(17)30820-0 [pii]
LID - 10.1016/j.neulet.2017.10.002 [doi]
AB  - Arginine vasopressin (AVP) plays an important role in thermoregulation and 
      antipyresis. We have demonstrated that AVP could change the spontaneous activity 
      of thermosensitive and temperature insensitive neurons in the preoptic area. 
      However, whether AVP influences the effects of prostaglandin E(2) (PGE(2)) on the 
      spontaneous activity of neurons in the medial preoptic area (MPO) remains 
      unclear. Our experiment showed that PGE(2) decreased the spontaneous activity of 
      warm-sensitive neurons, and increased that of low-slope temperature-insensitive 
      neurons in the MPO. AVP attenuated the inhibitory effect of PGE(2) on 
      warm-sensitive neurons, and reversed the excitatory effect of PGE(2) on low-slope 
      temperature-insensitive neurons, demonstrating that AVP antagonized the effects 
      of PGE(2) on the spontaneous activity of these neurons. The effect of AVP was 
      suppressed by an AVP V(1a) receptor antagonist, suggesting that V(1a) receptor 
      mediated the action of AVP. We also demonstrated that AVP attenuated the 
      PGE(2)-induced decrease in the prepotential's rate of rise in warm-sensitive 
      neurons and the PGE(2)-induced increase in that in low-slope 
      temperature-insensitive neurons through the V(1a) receptor. Together, these data 
      indicated that AVP antagonized the PGE(2)-induced change in the spontaneous 
      activity of warm-sensitive and low-slope temperature-insensitive neurons in the 
      MPO partly by reducing the PGE(2)-induced change in the prepotential of these 
      neurons in a V(1a) receptor-dependent manner.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Xu, Jian-Hui
AU  - Xu JH
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China.
FAU - Hou, Xiao-Yu
AU  - Hou XY
AD  - Department of Obstetrics, The First Affiliated Hospital of Chengdu Medical 
      College, Chengdu, Sichuan 610500, China.
FAU - Tang, Yu
AU  - Tang Y
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China.
FAU - Luo, Rong
AU  - Luo R
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China.
FAU - Liu, Chang
AU  - Liu C
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China.
FAU - Yang, Yong-Lu
AU  - Yang YL
AD  - Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu, 
      Sichuan 610500, China. Electronic address: ylyang9@sohu.com.
LA  - eng
PT  - Journal Article
DEP - 20171006
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 113-79-1 (Arginine Vasopressin)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*pharmacology
MH  - Cell Polarity
MH  - Dinoprostone/*pharmacology
MH  - Hot Temperature
MH  - In Vitro Techniques
MH  - Male
MH  - Neurons/*drug effects/physiology
MH  - Patch-Clamp Techniques
MH  - Preoptic Area/cytology/*drug effects
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Arginine vasopressin
OT  - Endogenous antipyretics
OT  - Medial preoptic area
OT  - Prostaglandin E(2)
OT  - Warm-sensitive neurons
EDAT- 2017/10/11 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/07/27 00:00 [received]
PHST- 2017/09/13 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
AID - S0304-3940(17)30820-0 [pii]
AID - 10.1016/j.neulet.2017.10.002 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Jan 1;662:59-64. doi: 10.1016/j.neulet.2017.10.002. Epub 2017 
      Oct 6.