PMID- 28990534
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180702
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Linking)
VI  - 15
IP  - 5
DP  - 2017 Nov 23
TI  - Association between Vitamin D Status, Oxidative Stress Biomarkers and Viral Load 
      in Human Immunodeficiency Virus Type 1 Infection.
PG  - 336-344
LID - 10.2174/1570162X15666171005170227 [doi]
AB  - BACKGROUND: The role of vitamin D in the pathophysiology of human 
      immunodeficiency virus type 1 (HIV-1) infection is still unclear. OBJECTIVE: To 
      evaluate the associations between vitamin D and immunological, virological, and 
      oxidative stress biomarkers in individuals with human immunodeficiency virus type 
      1 (HIV-1) infection. METHODS: The serum levels of 25 hydroxyvitamin D [25(OH)D] 
      were determined in 314 HIV-1- infected individuals and 127 controls and the 
      values >/=30 ng/mL defined a vitamin D sufficient (VDS) status, and <30 ng/mL 
      defined the presence of hypovitaminosis D (HD). Oxidative stress was evaluated 
      with plasma levels of lipid hydroperoxides, advanced oxidation protein products 
      (AOPP), carbonyl protein, nitric oxide metabolites (NOx), total radical-trapping 
      antioxidant parameter (TRAP), and sulfhydryl groups of proteins. Plasma HIV-1 
      viral load and CD4+/CD8+ T cells were quantified. RESULTS: The 25(OH)D levels and 
      vitamin D status did not differ between HIV-1-infected individuals and controls. 
      Hydroperoxides and AOPP were higher (p<0.0001 and p=0.002, respectively), whereas 
      TRAP, carbonyl protein, and NOx were lower in HIV-1-infected individuals than 
      controls (p<0.0001). HIV-1-infected individuals with HD showed higher 
      hydroperoxide levels than those with a VDS status (p=0.012) and controls 
      (p=0.022), independent of ethnicity and antiretroviral therapy. A positive 
      correlation between 25(OH)D >/=30 ng/mL and viral load was observed when expressed 
      as the number of copies/mL (r=0.178, p=0.039), as well as log10 copies/mL 
      (r=0.183, p=0.033). CONCLUSION: These results suggest the bimodal influence of 
      vitamin D in the modulation of immune response in HIV-1 infection, considering 
      its differential susceptibility to modulation of the various immune targets and 
      pathways.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Flauzino, Tamires
AU  - Flauzino T
AD  - Postgraduate Program, Health Sciences Center, State University of Londrina, 
      Londrina, Brazil.
FAU - Simao, Andrea N C
AU  - Simao ANC
AD  - Department of Pathology, Clinical and Toxicological Analysis, Health Sciences 
      Center, State University of Londrina, Londrina, Brazil.
FAU - de Almeida, Elaine R D
AU  - de Almeida ERD
AD  - Department of Pathology, Clinical and Toxicological Analysis, Health Sciences 
      Center, State University of Londrina, Londrina, Brazil.
FAU - Morimoto, Helena K
AU  - Morimoto HK
AD  - Department of Pathology, Clinical and Toxicological Analysis, Health Sciences 
      Center, State University of Londrina, Londrina, Brazil.
FAU - Oliveira, Sayonara R
AU  - Oliveira SR
AD  - Department of Pathology, Clinical and Toxicological Analysis, Health Sciences 
      Center, State University of Londrina, Londrina, Brazil.
FAU - Alfieri, Daniela F
AU  - Alfieri DF
AD  - Postgraduate Program, Health Sciences Center, State University of Londrina, 
      Londrina, Brazil.
FAU - Ueda, Luiz T
AU  - Ueda LT
AD  - Integrated Center of Infectious Diseases of 17a Secretariat of Health of Parana, 
      Londrina, Parana State, Brazil.
FAU - Dichi, Isaias
AU  - Dichi I
AD  - Department of Clinical Medicine, Health Sciences Center, State University of 
      Londrina, Londrina, Brazil.
FAU - Reiche, Edna M V
AU  - Reiche EMV
AD  - Department of Pathology, Clinical and Toxicological Analysis, Health Sciences 
      Center, State University of Londrina, Londrina, Brazil.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (Lipid Peroxides)
RN  - 1406-16-2 (Vitamin D)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Advanced Oxidation Protein Products/blood
MH  - CD4 Lymphocyte Count
MH  - CD4-CD8 Ratio
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*complications/*virology
MH  - HIV-1/*isolation & purification
MH  - Humans
MH  - Lipid Peroxides/blood
MH  - Male
MH  - Nitric Oxide/blood
MH  - *Oxidative Stress
MH  - Serum/chemistry
MH  - *Viral Load
MH  - Vitamin D/blood
MH  - *Vitamin D Deficiency
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - HIV-1 infection.
OT  - Human immunodeficiency virus infection
OT  - oxidative stress
OT  - viral load
OT  - vitamin D
EDAT- 2017/10/11 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/06/14 00:00 [received]
PHST- 2017/08/29 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
AID - CHR-EPUB-86227 [pii]
AID - 10.2174/1570162X15666171005170227 [doi]
PST - ppublish
SO  - Curr HIV Res. 2017 Nov 23;15(5):336-344. doi: 10.2174/1570162X15666171005170227.